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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Ability of a Combined FIB4/miRNA181a Score to Predict Significant Liver Fibrosis in NAFLD Patients

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Author(s):
Lima, Rodrigo Vieira Costa [1] ; Stefano, Jose Tadeu [1] ; Malta, Fernanda de Mello [1] ; Pinho, Joao Renato Rebello [1] ; Carrilho, Flair Jose [1] ; Arrese, Marco [2, 3] ; Oliveira, Claudia P. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Lab Gastroenterol Clin & Expt LIM 07, Div Clin Gastroenterol & Hepat, Dept Gastroenterol, Hosp Clin HCFMUSP, Fac Med, BR-05403000 Sao Paulo, SP - Brazil
[2] Pontificia Univ Catolica Chile, Escuela Med, Dept Gastroenterol, Santiago 8330024 - Chile
[3] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Dept Biol Celular & Mol, Ctr Envejecimiento & Regenerac CARE, Santiago 8330024 - Chile
Total Affiliations: 3
Document type: Journal article
Source: BIOMEDICINES; v. 9, n. 12 DEC 2021.
Web of Science Citations: 0
Abstract

Liver biopsy is the gold standard for assessing fibrosis, but there is a need to seek non-invasive biomarkers for this purpose. The aim of this study was to evaluate the correlation between the serum levels of the microRNAs miR-21, miR-29a, miR-122, miR-155 and miR-181a and the phenotypic expression of NAFLD. A cross-sectional study was carried out on 108 NAFLD patients diagnosed by liver biopsy. FIB-4 and NAFLD fibrosis scores were calculated. The comparison between the distributions of microRNA values according to the presence or absence of histological fibrosis (F2-F4) was performed. A multivariate logistic regression analysis was performed to build a score for predicting fibrosis using FIB-4 and Ln (miR-181a) as independent variables. Only miR-181a showed a statistical difference between patients with significant liver fibrosis (>F2) and those without (F0-F1) (p = 0.017). FIB-4 revealed an AUC on the ROC curve of 0.667 to predict clinically significant fibrosis (F2-F4). When assessed using the score in association with Ln (miR-181a), there was an improvement in the ROC curve, with an AUC of 0.71. miR-181a can be used as a non-invasive method of predicting fibrosis in NAFLD, and an association with FIB-4 has the potential to increase the accuracy of each method alone. (AU)

FAPESP's process: 18/03698-2 - The role of microRNAs in phenotipic expression of Non alcoholic fatty liver disease (NAFLD): since simple steatosis to hepatocellular carcinoma.
Grantee:Claudia Pinto Marques Souza de Oliveira
Support Opportunities: Regular Research Grants