Predictive factors of survival and score validation in liver retransplantation for Hepatitis C recurrence

• Grant number: 12/03895-6
• Support Opportunities: Scholarships abroad - Research
• Effective date (Start): June 25, 2012
• Effective date (End): May 30, 2013
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Alice Tung Wan Song
• Grantee: Alice Tung Wan Song
• Host Investigator: Didier Samuel
• Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Research place: Université Paris-Sud (Paris 11), France

Abstract

Advanced liver disease caused by hepatitis C virus is the leading cause of liver transplantation in Western countries. Disease progression is particularly aggressive in transplanted patients, with rapid evolution towards fibrosis. In patients with established cirrhosis and graft failure, retransplantation is the only therapeutic option. Retransplantation in individuals with hepatitis C recurrence is controversial, seeing that in some studies it represents a risk factor for mortality. Several scores have been designed in order to predict survival and aid in retransplantation indication. Recently, a score specifically designed for patients with hepatitis C has been published. Objectives: To identify survival predictive factors in patients submitted to retransplantation for hepatitis C recurrence; to validate and, depending on the results, to modify a survival score in this population. Methods: Retrospective analysis of retransplantation cases due to hepatitis C recurrence at Paul Brousse Hospital. Donor and recipients' characteristics from the first and the second transplants will be revised, and patient and graft survival from the second transplant will be established. Primary outcome will be survival in 1, 3, 5, and 10 years, and the variables will be analyzed as survival predictive factors through univariate and multivariate analysis. A previously published survival score will be validated and its modification may be proposed according to results. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

WAN SONG, ALICE TUNG; SOBESKY, RODOLPHE; VINAIXA, CARMEN; DUMORTIER, JEROME; RADENNE, SYLVIE; DURAND, FRANOIS; CALMUS, YVON; ROUSSEAU, GERALDINE; LATOURNERIE, MARIANNE; FERAY, CYRILLE; et al. Predictive factors for survival and score application in liver retransplantation for hepatitis C recurrence. WORLD JOURNAL OF GASTROENTEROLOGY, v. 22, n. 18, p. 4547-4558, MAY 14 2016. (12/03895-6)