Unraveiling the correlation among neurodevelopmental and inflammatory biomarkers in patients with chronic schizophrenia

Autor(es)

Nani, V, Joao ; Almeida, Priscila G. C. ^[1] ; Noto, Cristiano ^[2] ; Bressan, Rodrigo A. ^[2] ; Brietzke, Elisa ^[3] ; Hayashi, Mirian A. F. ^{[1, 4]}

Afiliação do(s) autor(es)

^[1] Nani, Joao, V, Univ Fed Sao Paulo UNIFESP, Dept Pharmacol, Escola Paulista Med EPM, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Dept Psychiat, Escola Paulista Med EPM, Sao Paulo - Brazil

^[3] Queens Univ, Dept Psychiat, Sch Med, Kingston, ON K7L 3N6 - Canada

^[4] Nani, Joao, V, Natl Inst Translat Med INCT TM, CNPq, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NORDIC JOURNAL OF PSYCHIATRY; JAN 2022.
• Citações Web of Science: 0

Resumo

Introduction Nuclear distribution element like-1 (Ndel1) is a cytosolic oligopeptidase, which was suggested as a potential biomarker of aberrant neurodevelopment and early stage of schizophrenia (SCZ). The involvement of Ndel1 in neurite outgrowth, neuronal migration and neurodevelopment was demonstrated. Moreover, Ndel1 cleaves neuropeptides, including the endogenous antipsychotic peptide neurotensin, and lower Ndel1 activity was reported in SCZ patients compared with healthy controls (HCs). Changes in brain-derived neurotrophic factor (BDNF) and inflammatory cytokines levels were also implicated in SCZ. Objective This preliminary study aimed to investigate the interactions between these immune and neurodevelopmental/neurotrophic biomarkers, namely BDNF and the recently identified SCZ biomarker Ndel1. Results We observed lower Ndel1 activity and IL-4 levels, and higher BDNF levels, in plasma of SCZ (N = 23) compared with HCs (N = 29). Interestingly, significant correlation between Ndel1 activity and IL-4 levels was observed in SCZ, while no correlation with any other evaluated interleukins (namely IL-2, IL-8, IL-10 and IL-17A) or BDNF levels was noticed. Conclusion Although this hypothesis needs to be further explored for a better understanding of the mechanisms by which these altered pathways are associated to each other in SCZ, we suggest that Ndel1 and the inflammatory marker IL-4 are directly correlated. (AU)

• Processo FAPESP: 19/09207-3 - Estudo do(s) mecanismo(s) molecular(es) e celular(es) em transtornos mentais
• Beneficiário: João Victor Silva Nani
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/20014-0 - Conectando o intestino e o cérebro: envolvimento do microbioma intestinal no surgimento e progressão da doença de Parkinson esporádica
• Beneficiário: Matheus de Castro Fonseca
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/02413-1 - Validação da crotamina como biomarcador e avaliação do seu potencial uso na terapia de doenças humanas
• Beneficiário: Mirian Akemi Furuie Hayashi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/50891-1 - INCT 2014: Translacional em Medicina
• Beneficiário: Jaime Eduardo Cecilio Hallak
• Modalidade de apoio: Auxílio à Pesquisa - Temático