14-3-3 proteins at the crossroads of neurodevelopment and schizophrenia

Autor(es)

Antunes, Andre S. L. M. ^[1] ; Saia-Cereda, Veronica M. ^[1] ; Crunfli, Fernanda ^[1] ; Martins-de-Souza, Daniel ^{[2, 3, 4, 1]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Lab Neuroprote, 255 Bloco F Sala 1, Cidade Univ Zeferino Vaz, BR-13083862 Campinas, SP - Brazil

^[2] Conselho Nacl Desenvolvimento Cient & Tecnol, Inst Nacl Biomarcadores Neuropsiquiatria INBION, Sao Paulo, SP - Brazil

^[3] Univ Estadual Campinas, Expt Med Res Cluster EMRC, Campinas, SP - Brazil

^[4] DOr Inst Res & Educ IDOR, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY; v. 23, n. 1, p. 14-32, JAN 2 2022.
• Citações Web of Science: 0

Resumo

The 14-3-3 family comprises multifunctional proteins that play a role in neurogenesis, neuronal migration, neuronal differentiation, synaptogenesis and dopamine synthesis. 14-3-3 members function as adaptor proteins and impact a wide variety of cellular and physiological processes involved in the pathophysiology of neurological disorders. Schizophrenia is a psychiatric disorder and knowledge about its pathophysiology is still limited. 14-3-3 have been proven to be linked with the dopaminergic, glutamatergic and neurodevelopmental hypotheses of schizophrenia. Further, research using genetic models has demonstrated the role played by 14-3-3 proteins in neurodevelopment and neuronal circuits, however a more integrative and comprehensive approach is needed for a better understanding of their role in schizophrenia. For instance, we still lack an integrated assessment of the processes affected by 14-3-3 proteins in the dopaminergic and glutamatergic systems. In this context, it is also paramount to understand their involvement in the biology of brain cells other than neurons. Here, we present previous and recent research that has led to our current understanding of the roles 14-3-3 proteins play in brain development and schizophrenia, perform an assessment of their functional protein association network and discuss the use of protein-protein interaction modulators to target 14-3-3 as a potential therapeutic strategy. (AU)

• Processo FAPESP: 19/22398-2 - O papel da síntese de colesterol no mecanismo de ação da clozapina em modelos experimentais para esquizofrenia
• Beneficiário: Fernanda Crunfli
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 16/07332-7 - O papel das vias de sinalização 14-3-3 e Efrina na comunicação celular entre neurônios-astrócitos e funcionamento da sinapse tripartite
• Beneficiário: Verônica Aparecida Monteiro Saia Cereda
• Modalidade de apoio: Bolsas no Brasil - Doutorado