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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

14-3-3 proteins at the crossroads of neurodevelopment and schizophrenia

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Author(s):
Antunes, Andre S. L. M. [1] ; Saia-Cereda, Veronica M. [1] ; Crunfli, Fernanda [1] ; Martins-de-Souza, Daniel [2, 3, 4, 1]
Total Authors: 4
Affiliation:
[1] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Lab Neuroprote, 255 Bloco F Sala 1, Cidade Univ Zeferino Vaz, BR-13083862 Campinas, SP - Brazil
[2] Conselho Nacl Desenvolvimento Cient & Tecnol, Inst Nacl Biomarcadores Neuropsiquiatria INBION, Sao Paulo, SP - Brazil
[3] Univ Estadual Campinas, Expt Med Res Cluster EMRC, Campinas, SP - Brazil
[4] DOr Inst Res & Educ IDOR, Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Review article
Source: WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY; v. 23, n. 1, p. 14-32, JAN 2 2022.
Web of Science Citations: 0
Abstract

The 14-3-3 family comprises multifunctional proteins that play a role in neurogenesis, neuronal migration, neuronal differentiation, synaptogenesis and dopamine synthesis. 14-3-3 members function as adaptor proteins and impact a wide variety of cellular and physiological processes involved in the pathophysiology of neurological disorders. Schizophrenia is a psychiatric disorder and knowledge about its pathophysiology is still limited. 14-3-3 have been proven to be linked with the dopaminergic, glutamatergic and neurodevelopmental hypotheses of schizophrenia. Further, research using genetic models has demonstrated the role played by 14-3-3 proteins in neurodevelopment and neuronal circuits, however a more integrative and comprehensive approach is needed for a better understanding of their role in schizophrenia. For instance, we still lack an integrated assessment of the processes affected by 14-3-3 proteins in the dopaminergic and glutamatergic systems. In this context, it is also paramount to understand their involvement in the biology of brain cells other than neurons. Here, we present previous and recent research that has led to our current understanding of the roles 14-3-3 proteins play in brain development and schizophrenia, perform an assessment of their functional protein association network and discuss the use of protein-protein interaction modulators to target 14-3-3 as a potential therapeutic strategy. (AU)

FAPESP's process: 19/22398-2 - The role of cholesterol synthesis in the mode of action of clozapine in schizophrenia models
Grantee:Fernanda Crunfli
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/07332-7 - The role of 14-3-3 and Ephrin signaling pathways on cellular communication between neurons-astrocytes and the functioning of the synapse tripartite
Grantee:Verônica Aparecida Monteiro Saia Cereda
Support Opportunities: Scholarships in Brazil - Doctorate