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The role of 14-3-3 and Ephrin signaling pathways on cellular communication between neurons-astrocytes and the functioning of the synapse tripartite

Grant number: 16/07332-7
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2016
Effective date (End): July 31, 2021
Field of knowledge:Biological Sciences - Biochemistry - Chemistry of Macromolecules
Principal researcher:Daniel Martins-de-Souza
Grantee:Verônica Aparecida Monteiro Saia Cereda
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:13/08711-3 - Developing a predictive test for a successful medication response and understanding the molecular bases of schizophrenia through proteomics, AP.JP
Associated scholarship(s):18/07034-1 - The role of D-Serine in the cellular communication between neurons and astrocytes during neurodevelopment, BE.EP.DR

Abstract

Schizophrenia (SCZ) is an incurable mental disorder of neurodevelopmental origin which affects about 1% of world population. This disease is among the largest causes of disability and may represent costs in the order of 60 billion dollars per year for the health systems. Part of the molecular aspects of SCZ have been recently elucidated, including those in postmortem brains. However, results still need to be better connected to an integrated understanding of its pathophysiology. In this context, this project proposes to study the Ephrin/14-3-3 signaling pathways, which were found dysregulated during the master's project of the proponent, while studying the proteome of human brain tissue. The present study aims to connect Ephrin/14-3-3 to other molecular aspects already elucidated in schizophrenia. Additionally, we intend to determine the role of these pathways in synaptic plasticity, the main modulator of memory, learning and cognition, which are all dysregulated in patients with SCZ.

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DEZONNE, ROMULO SPERDUTO; SARTORE, RAFAELA COSTA; NASCIMENTO, JULIANA MINARDI; SAIA-CEREDA, VERONICA M.; ROMAO, LUCIANA FERREIRA; ALVES-LEON, SONIZA VIEIRA; DE SOUZA, JORGE MARCONDES; MARTINS-DE-SOUZA, DANIEL; REHEN, STEVENS KASTRUP; ALCANTARA GOMES, FLVIA CARVALHO. Derivation of Functional Human Astrocytes from Cerebral Organoids. SCIENTIFIC REPORTS, v. 7, . (16/07332-7, 14/10068-4, 13/08711-3, 14/21035-0)
NASCIMENTO, JULIANA MINARDI; SAIA-CEREDA, VERONICA M.; SARTORE, RAFAELA C.; DA COSTA, RODRIGO MADEIRO; SCHITINE, CLARISSA S.; FREITAS, HERCULES REZENDE; MURGU, MICHAEL; DE MELO REIS, RICARDO A.; REHEN, STEVENS K.; MARTINS-DE-SOUZA, DANIEL. Human Cerebral Organoids and Fetal Brain Tissue Share Proteomic Similarities. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, v. 7, . (14/21035-0, 14/10068-4, 13/08711-3, 16/07332-7)
ANTUNES, ANDRE S. L. M.; SAIA-CEREDA, VERONICA M.; CRUNFLI, FERNANDA; MARTINS-DE-SOUZA, DANIEL. 14-3-3 proteins at the crossroads of neurodevelopment and schizophrenia. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, v. 23, n. 1, p. 14-32, . (19/22398-2, 16/07332-7)
ZUCCOLI, GIULIANA S.; SAIA-CEREDA, VERONICA M.; NASCIMENTO, JULIANA M.; MARTINS-DE-SOUZA, DANIEL. The Energy Metabolism Dysfunction in Psychiatric Disorders Postmortem Brains: Focus on Proteomic Evidence. FRONTIERS IN NEUROSCIENCE, v. 11, . (14/10068-4, 16/07332-7, 16/04912-2, 13/08711-3, 14/21035-0)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.