Photophysical, photooxidation, and biomolecule-interaction of meso-tetra(thienyl)porphyrins containing peripheral Pt(ii) and Pd(ii) complexes. Insights for photodynamic therapy applications

Autor(es)

Tisoco, Isadora ^[1] ; Donatoni, Maria Carolina ^[2] ; Vieira Victoria, Henrique Fernandes ^[3] ; de Toledo, Jose Roberto ^[3] ; Krambrock, Klaus ^[3] ; Chaves, Otavio Augusto ^[4] ; de Oliveira, Kleber Thiago ^[2] ; Iglesias, Bernardo Almeida ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Santa Maria, Dept Chem, Av Roraima, Santa Maria, RS - Brazil

^[2] Univ Fed Sao Carlos, Dept Chem, Rod Washington Luiz, Sao Carlos, SP - Brazil

^[3] Univ Fed Minas Gerais, Dept Phys, Av Antonio Carlos, Belo Horizonte, MG - Brazil

^[4] Univ Coimbra, Dept Chem, Rua Larga, Coimbra - Portugal

• Tipo de documento: Artigo Científico
• Fonte: DALTON TRANSACTIONS; v. 51, n. 4 JAN 2022.
• Citações Web of Science: 0

Resumo

We report the synthesis and characterization of two novel tetra-cationic porphyrins, containing Pt(ii) or Pd(ii) polypyridyl complexes attached at the peripheral position of N-4-macrocycle. Compounds were characterized through elemental analysis, molar conductivity, cyclic voltammetry, and spectroscopy analysis. Photophysical and photobiological parameters were also evaluated. Also, the binding capacity of each porphyrin with human serum albumin (HSA) was determined by UV-Vis, steady-state, and time-resolved fluorescence spectroscopy, combined with molecular docking calculations. The results suggest that the interaction of these compounds is spontaneous, weak to moderate, and probably occurs at site III (subdomain IB) by non-covalent forces, including van der Waals and H-bonding. Moreover, porphyrins containing peripheral complexes improve their interactions with biomolecules, show good photostability, generate reactive oxygen species under white light studied by electron paramagnetic resonance (EPR) analysis, and promote photo-damage of HSA. (AU)

• Processo FAPESP: 19/27176-8 - Fotocatálise assimétrica aplicada à síntese do medicamento Brivaracetam: abordagens sintéticas empregando tecnologias facilitadoras de síntese química
• Beneficiário: Kleber Thiago de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 20/06874-6 - Aplicações das metodologias e tecnologias de síntese em regime de fluxo contínuo desenvolvidas no LQBO-UFSCar na preparação de moléculas com atividades biológicas e IFAs
• Beneficiário: Kleber Thiago de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/07276-1 - CEPOF - Centro de Pesquisa em Óptica e Fotônica
• Beneficiário: Vanderlei Salvador Bagnato
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs