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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Photophysical, photooxidation, and biomolecule-interaction of meso-tetra(thienyl)porphyrins containing peripheral Pt(ii) and Pd(ii) complexes. Insights for photodynamic therapy applications

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Author(s):
Tisoco, Isadora [1] ; Donatoni, Maria Carolina [2] ; Vieira Victoria, Henrique Fernandes [3] ; de Toledo, Jose Roberto [3] ; Krambrock, Klaus [3] ; Chaves, Otavio Augusto [4] ; de Oliveira, Kleber Thiago [2] ; Iglesias, Bernardo Almeida [1]
Total Authors: 8
Affiliation:
[1] Univ Fed Santa Maria, Dept Chem, Av Roraima, Santa Maria, RS - Brazil
[2] Univ Fed Sao Carlos, Dept Chem, Rod Washington Luiz, Sao Carlos, SP - Brazil
[3] Univ Fed Minas Gerais, Dept Phys, Av Antonio Carlos, Belo Horizonte, MG - Brazil
[4] Univ Coimbra, Dept Chem, Rua Larga, Coimbra - Portugal
Total Affiliations: 4
Document type: Journal article
Source: DALTON TRANSACTIONS; v. 51, n. 4 JAN 2022.
Web of Science Citations: 0
Abstract

We report the synthesis and characterization of two novel tetra-cationic porphyrins, containing Pt(ii) or Pd(ii) polypyridyl complexes attached at the peripheral position of N-4-macrocycle. Compounds were characterized through elemental analysis, molar conductivity, cyclic voltammetry, and spectroscopy analysis. Photophysical and photobiological parameters were also evaluated. Also, the binding capacity of each porphyrin with human serum albumin (HSA) was determined by UV-Vis, steady-state, and time-resolved fluorescence spectroscopy, combined with molecular docking calculations. The results suggest that the interaction of these compounds is spontaneous, weak to moderate, and probably occurs at site III (subdomain IB) by non-covalent forces, including van der Waals and H-bonding. Moreover, porphyrins containing peripheral complexes improve their interactions with biomolecules, show good photostability, generate reactive oxygen species under white light studied by electron paramagnetic resonance (EPR) analysis, and promote photo-damage of HSA. (AU)

FAPESP's process: 19/27176-8 - Asymmetric photocatalysis applied to the synthesis of Brivaracetam: synthetic approaches employing enabling technologies for chemical synthesis
Grantee:Kleber Thiago de Oliveira
Support Opportunities: Regular Research Grants
FAPESP's process: 20/06874-6 - Applications of technologies and synthetic methodologies developed under continuous flow conditions at LQBO-UFSCar for the preparation of molecules with biological activities and APIs
Grantee:Kleber Thiago de Oliveira
Support Opportunities: Regular Research Grants
FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
Grantee:Vanderlei Salvador Bagnato
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC