ffects of virtual reality-based motor rehabilitation: a systematic review of fMRI studie

Autor(es)

Feitosa, Jamille A. ^{[1, 2]} ; Fernandes, Corina A. ^{[1, 2]} ; Casseb, Raphael F. ^{[3, 2]} ; Castellano, Gabriela ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Phys Gleb Wataghin, Neurophys Grp, Campinas - Brazil

^[2] Brazilian Inst Neurosci & Neurotechnol BRAINN, Campinas - Brazil

^[3] Univ Estadual Campinas, Dept Neurol, Neuroimaging Lab, Campinas - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF NEURAL ENGINEERING; v. 19, n. 1 FEB 1 2022.
• Citações Web of Science: 0

Resumo

Background. The use of virtual reality (VR) as a rehabilitation tool has been shown to induce motor and cognitive improvements in different populations. Functional magnetic resonance imaging (fMRI) has been used to investigate neuroplasticity resulting from these treatments. We hypothesize that VR rehabilitation induces functional improvement and brain changes that can be detected by fMRI. Objective. To systematically review the effects of VR intervention on the cortical reorganization measured by fMRI and associated with functional improvement. Approach. We performed a systematic review of studies published between 2005 and 2021. Papers were retrieved from six databases using the following keywords: `motor rehabilitation', `fMRI' and `virtual reality'. Case studies, pre-post studies, cross-sectional studies, and randomized controlled trials published were included. Manuscripts were assessed by The National Institutes of Health study quality assessment tools to determine their quality. Main results. Twenty-three articles met our eligibility criteria: 18 about VR rehabilitation in stroke and five on other clinical conditions (older adults, cerebral palsy, and Parkinson's disease). Changes in neural patterns of activation and reorganization were revealed in both the ipsilesional and the contralesional hemispheres. Results were located mainly in the primary motor cortex, sensorimotor cortex and supplementary motor area in post-stroke patients in the acute, subacute, and chronic rehabilitation phases, and were associated with functional improvement after VR intervention. Similar effects were observed in older adults and in patients with other neurological diseases with improved performance. Significance. Most stroke-related studies showed either restoration to normal or increase of activation patterns or relateralization at/to the ipsilesional hemisphere, with some also reporting a decrease in activity or extent of activation after VR therapy. In general, VR intervention demonstrated evidence of efficacy both in neurological rehabilitation and in performance improvement of older adults, accompanied by fMRI evidence of brain reorganization. (AU)

• Processo FAPESP: 20/00019-7 - Análise avançada da ressonância magnética na epilepsia para prever o resultado do tratamento cirúrgico: uma abordagem de aprendizado de máquina
• Beneficiário: Raphael Fernandes Casseb
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 20/10644-6 - Neuromodulação combinada a outras neurotecnologias para aplicação na reabilitação motora de pacientes de AVC
• Beneficiário: Corina Aparecida Fernandes
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado