novel hypermucoviscous Klebsiella pneumoniae ST3994-K2 clone belonging to Clonal Group 8

Autor(es):Mostrar menos -

Cerdeira, Louise ^{[1, 2]} ; Nakamura-Silva, Rafael ^[3] ; Oliveira-Silva, Mariana ^[3] ; Sano, Elder ^{[4, 5]} ; Esposito, Fernanda ^{[5, 6]} ; Fuga, Bruna ^{[4, 5]} ; Moura, Quezia ^[7] ; Saraiva Miranda, Carlos Eduardo ^[8] ; Wyres, Kelly ^[1] ; Lincopan, Nilton ^{[4, 5, 6]} ; Pitondo-Silva, Andre ^{[3, 8]}

Afiliação do(s) autor(es)

^[1] Monash Univ, Cent Clin Sch, Dept Infect Dis, Melbourne, Vic 3800 - Australia

^[2] Univ Liverpool Liverpool Sch Trop Med, Dept Vector Biol, Liverpool L3 5QA, Merseyside - England

^[3] Univ Ribeirao Preto, Postgrad Program Environm Technol, BR-14096900 Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Inst Biomed Sci, BR-05508000 Sao Paulo, SP - Brazil

^[5] Univ Sao Paulo, One Hlth Brazilian Resistance Project OneBR, BR-05508000 Sao Paulo, SP - Brazil

^[6] Univ Sao Paulo, Sch Pharm, Dept Clin Anal, BR-05508000 Sao Paulo, SP - Brazil

^[7] Fed Inst Educ Sci & Technol Espirito Santo, BR-29106010 Vila Velha - Brazil

^[8] Univ Ribeirao Preto, Postgrad Program Dent, BR-14096900 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PATHOGENS AND DISEASE; v. 79, n. 8 NOV 2021.
• Citações Web of Science: 0

Resumo

Emergent hypervirulent Klebsiella pneumoniae has been responsible for severe diseases, representing a serious threat to public health. We report the whole-genome sequencing of a novel ST3994-K2 clone, a single locus variant of ST86 K2, which is considered a worrying hypervirulent clone that emerged in several parts of the world. The strain K. pneumonia Kpi144 was isolated in 2013 from a blood culture of a 69-year-old male patient admitted to a tertiary hospital in Teresina, state of Piaui, northeastern Brazil. The strain was susceptible to 41 antibiotics tested, presented hypermucoviscous phenotype and a virulent behavior was observed in the Galleria mellonella infection model. Moreover, the virulome showed several virulence genes. To the best of our knowledge, this is the first worldwide report of a novel ST3994-K2 K. pneumoniae clone, an SLV of ST86 K2, which is considered a worrying virulent clone that has emerged in several parts of the world, including South America and Brazil. (AU)

• Processo FAPESP: 13/22581-5 - Estudo dos mecanismos de patogenicidade e correlação com resistência a antimicrobianos de Klebsiella pneumoniae isoladas no Brasil e em países dos cinco continentes
• Beneficiário: André Pitondo da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores