Acceptability and effect of TiF4 on dental caries: a randomized controlled clinical trial

Autor(es)

de Souza, Beatriz Martines ^[1] ; Silva, Mayara de Souza ^[1] ; Braga, Aline Silva ^[1] ; Soares dos Santos, Daiana Moreli ^[1] ; Carvalho, Thamyris de Souza ^[1] ; dos Santos, Natalia Mello ^[2] ; Rios, Daniela ^[2] ; Rabelo Buzalaf, Marilia Afonso ^[1] ; Magalhaes, Ana Carolina ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Bauru, SP - Brazil

^[2] Univ Sao Paulo, Bauru Sch Dent, Dept Pediat Dent Orthodont & Publ Hlth, Bauru, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Oral Research; v. 35, 2021.
• Citações Web of Science: 1

Resumo

Abstract: This randomized three-armed controlled clinical trial compared the effect of titanium tetrafluoride (TiF4) and sodium fluoride (NaF) varnishes on caries control in smooth surfaces of permanent dentition and children's acceptability. Sixty children (6-8 y/o) were randomly divided into TiF4 (2.45% F–), NaF (2.26% F–) or placebo (control) groups. Varnishes were applied on permanent teeth once a week for the first 4 weeks and after the 6th and 12th months of the study. The variables were as follows: International Caries Detection and Assessment System (ICDAS) scores, quantitative fluorescence changes, visual plaque index (VPI) and degree of acceptability. Two-way RM-ANOVA, ANOVA/Tukey and χ2 tests were performed (p < 0.05). No differences were found between the treatments with respect to ICDAS scores (p = 0.32). Only TiF4 reduced the mean fluorescence loss significantly at 18 months compared to the baseline (p = 0.003). TiF4 showed a lower percentage of new caries lesions by tooth surface than the placebo, while NaF did not induce such a change (p < 0.014). Regardless of the treatment, more than 95% of the participants reported being satisfied. For all groups, the VPI decreased significantly at 3 months compared to the baseline value (p < 0.001), with no differences between the treatments (p = 0.17). TiF4 had a similar ability to control caries lesions as NaF; however, only TiF4 differed from the placebo (p = 0.004). The acceptability of TiF4 varnish was similar to that of NaF varnish. (AU)

• Processo FAPESP: 15/14149-1 - Efeito de um verniz de TiF4 na prevenção e remineralização de lesões cariosas na dentição permanente de crianças residentes em área fluoretada: estudo clínico randomizado de 18 meses
• Beneficiário: Beatriz Martines de Souza
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/07241-0 - Efeito de formulações de saliva artificial e aplicação de fluoretos sobre o desenvolvimento de cárie radicular em modelo de biofilme microcosmo simulando pacientes submetidos à radiação de cabeça e pescoço
• Beneficiário: Beatriz Martines de Souza
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado