Acceptability and effect of TiF4 on dental caries: a randomized controlled clinical trial

Author(s)

de Souza, Beatriz Martines ^[1] ; Silva, Mayara de Souza ^[1] ; Braga, Aline Silva ^[1] ; Soares dos Santos, Daiana Moreli ^[1] ; Carvalho, Thamyris de Souza ^[1] ; dos Santos, Natalia Mello ^[2] ; Rios, Daniela ^[2] ; Rabelo Buzalaf, Marilia Afonso ^[1] ; Magalhaes, Ana Carolina ^[1]

Affiliation

^[1] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Bauru, SP - Brazil

^[2] Univ Sao Paulo, Bauru Sch Dent, Dept Pediat Dent Orthodont & Publ Hlth, Bauru, SP - Brazil

• Document type: Journal article
• Source: Brazilian Oral Research; v. 35, 2021.
• Web of Science Citations: 1

Abstract

Abstract: This randomized three-armed controlled clinical trial compared the effect of titanium tetrafluoride (TiF4) and sodium fluoride (NaF) varnishes on caries control in smooth surfaces of permanent dentition and children's acceptability. Sixty children (6-8 y/o) were randomly divided into TiF4 (2.45% F–), NaF (2.26% F–) or placebo (control) groups. Varnishes were applied on permanent teeth once a week for the first 4 weeks and after the 6th and 12th months of the study. The variables were as follows: International Caries Detection and Assessment System (ICDAS) scores, quantitative fluorescence changes, visual plaque index (VPI) and degree of acceptability. Two-way RM-ANOVA, ANOVA/Tukey and χ2 tests were performed (p < 0.05). No differences were found between the treatments with respect to ICDAS scores (p = 0.32). Only TiF4 reduced the mean fluorescence loss significantly at 18 months compared to the baseline (p = 0.003). TiF4 showed a lower percentage of new caries lesions by tooth surface than the placebo, while NaF did not induce such a change (p < 0.014). Regardless of the treatment, more than 95% of the participants reported being satisfied. For all groups, the VPI decreased significantly at 3 months compared to the baseline value (p < 0.001), with no differences between the treatments (p = 0.17). TiF4 had a similar ability to control caries lesions as NaF; however, only TiF4 differed from the placebo (p = 0.004). The acceptability of TiF4 varnish was similar to that of NaF varnish. (AU)

• FAPESP's process: 15/14149-1 - Effect of a TiF4 varnish in the prevention and remineralization of caries lesions in permanent teeth of children living in a fluoridated region: randomized clinical trial of 18 months
• Grantee: Beatriz Martines de Souza
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/07241-0 - Effect of artificial saliva substitutes and fluoride application on the development of root caries under a microcosm biofilm model simulating patients subjected to head and neck radiation
• Grantee: Beatriz Martines de Souza
• Support Opportunities: Scholarships in Brazil - Post-Doctoral