rinary metabolic biomarkers of diet quality in European children are associated with metabolic healt

Autor(es):Mostrar menos -

Stratakis, Nikos ^[1] ; Siskos, Alexandros P. ^{[2, 3]} ; Papadopoulou, Eleni ^[4] ; Nguyen, Anh N. ^[5] ; Zhao, Yinqi ^[1] ; Margetaki, Katerina ^[1] ; Lau, Chung-Ho E. ^{[2, 3, 6]} ; Coen, Muireann ^{[2, 3, 7]} ; Maitre, Lea ^{[8, 9, 10]} ; Fernandez-Barres, Silvia ^{[8, 9, 10]} ; Agier, Lydiane ^[11] ; Andrusaityte, Sandra ^[12] ; Basagana, Xavier ^{[8, 9, 10]} ; Brantsaeter, Anne Lise ^[4] ; Casas, Maribel ^{[8, 9, 10]} ; Fossati, Serena ^{[8, 9, 10]} ; Grazuleviciene, Regina ^[12] ; Heude, Barbara ^[13] ; McEachan, Rosemary R. C. ^[14] ; Meltzer, Helle Margrete ^[4] ; Millett, Christopher ^{[15, 16]} ; Rauber, Fernanda ^{[15, 17, 16]} ; Robinson, Oliver ^[6] ; Roumeliotaki, Theano ^[18] ; Borras, Eva ^{[9, 19]} ; Sabido, Eduard ^{[9, 19]} ; Urquiza, Jose ^{[8, 9, 10]} ; Vafeiadi, Marina ^[18] ; Vineis, Paolo ^[6] ; Voortman, Trudy ^[5] ; Wright, John ^[14] ; Conti, V, David ; Vrijheid, Martine ^{[8, 9, 10]} ; Keun, Hector C. ^{[2, 3]} ; Chatzi, Leda ^[20]

Afiliação do(s) autor(es):Mostrar menos -

^[1] Univ Southern Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90007 - USA

^[2] Imperial Coll London, Canc Metab & Syst Toxicol Grp, Div Canc, Dept Surg & Canc, Hammersmith Hosp Campus, London - England

^[3] Imperial Coll London, Div Syst Med, Dept Metab Digest & Reprod, Hammersmith Hosp Campus, London - England

^[4] Norwegian Inst Publ Hlth, Oslo - Norway

^[5] Erasmus MC, Dept Epidemiol, Rotterdam - Netherlands

^[6] Imperial Coll London, MRC Ctr Environm & Hlth, Sch Publ Hlth, London - England

^[7] AstraZeneca, Oncol Safety Clin Pharmacol & Safety Sci, R&D, Cambridge - England

^[8] Univ Pompeu Fabra, Barcelona - Spain

^[9] ISGlobal, Barcelona - Spain

^[10] CIBER Epidemiol & Salud Publ, Madrid - Spain

^[11] Univ Grenoble Alpes, IAB, Team Environm Epidemiol Appl Reprod & Resp Hlth, CNRS, INSERM, Grenoble - France

^[12] Vytautas Magnus Univ, Dept Environm Sci, Kaunas - Lithuania

^[13] Univ Paris, Ctr Res Epidemiol & Stat, INRA, INSERM, Paris - France

^[14] Bradford Teaching Hosp NHS Fdn Trust, Bradford Inst Hlth Res, Bradford, W Yorkshire - England

^[15] Univ Sao Paulo, Sch Med, Dept Prevent Med, Sao Paulo - Brazil

^[16] Imperial Coll, Sch Publ Hlth, Publ Hlth Policy Evaluat Unit, London - England

^[17] Univ Sao Paulo, Ctr Epidemiol Res Nutr & Hlth, Sao Paulo - Brazil

^[18] Univ Crete, Fac Med, Dept Social Med, Iraklion - Greece

^[19] Barcelona Inst Sci & Technol, Ctr Genom Regulat, Barcelona - Spain

^[20] Conti, David, V, Univ Southern Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90007 - USA

• Tipo de documento: Artigo Científico
• Fonte: eLIFE; v. 11, JAN 25 2022.
• Citações Web of Science: 0

Resumo

Urinary metabolic profiling is a promising powerful tool to reflect dietary intake and can help understand metabolic alterations in response to diet quality. Here, we used H-1 NMR spectroscopy in a multicountry study in European children (1147 children from 6 different cohorts) and identified a common panel of 4 urinary metabolites (hippurate, N-methylnicotinic acid, urea, and sucrose) that was predictive of Mediterranean diet adherence (KIDMED) and ultra-processed food consumption and also had higher capacity in discriminating children's diet quality than that of established sociodemographic determinants. Further, we showed that the identified metabolite panel also reflected the associations of these diet quality indicators with C-peptide, a stable and accurate marker of insulin resistance and future risk of metabolic disease. This methodology enables objective assessment of dietary patterns in European child populations, complementary to traditional questionary methods, and can be used in future studies to evaluate diet quality. Moreover, this knowledge can provide mechanistic evidence of common biological pathways that characterize healthy and unhealthy dietary patterns, and diet-related molecular alterations that could associate to metabolic disease. (AU)

• Processo FAPESP: 16/14302-7 - Consumo de alimentos ultraprocessados e indicadores de qualidade nutricional da dieta na Austrália
• Beneficiário: Fernanda Rauber
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/19820-1 - Consumo de alimentos ultraprocessados e obesidade na coorte Biobank do Reino Unido
• Beneficiário: Fernanda Rauber
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado