esoporous Silica-Fe3O4 Nanoparticle Composites as Potential Drug Carrier

Autor(es):Mostrar menos -

Losito, Danilo Waismann ^[1] ; de Araujo, Daniele Ribeiro ^[2] ; Nonato Bezzon, Vinicius Danilo ^[2] ; Oseliero Filho, Pedro Leonidas ^[3] ; Affonso Fonseca, Fernando Luiz ^{[4, 5]} ; Chagas, Camila dos Santos ^[5] ; Barbosa, Emerson ^[5] ; Pinto Oliveira, Cristiano Luis ^[3] ; de Abreu Fantini, Marcia Carvalho ^[3] ; Ferreira, Fabio Furlan ^[2] ; Martins, Tereza da Silva ^[1] ; Haddad, Paula Silvia ^[1]

Afiliação do(s) autor(es)

^[1] Fed Univ Sao Paulo UNIFESP, Dept Chem, BR-09913030 Diadema, SP - Brazil

^[2] Fed Univ ABC UFABC, Ctr Human & Nat Sci CCNH, BR-09210580 Santo Andre, SP - Brazil

^[3] Univ Sao Paulo, Inst Phys, BR-05508060 Sao Paulo, SP - Brazil

^[4] Fed Univ Sao Paulo UNIFESP, Dept Pharmaceut Sci, BR-09913030 Diadema, SP - Brazil

^[5] ABC Hlth Univ Ctr, Fac Med ABC, BR-09060870 Santo Andre, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ACS APPLIED NANO MATERIALS; v. 4, n. 12, p. 13363-13378, DEC 24 2021.
• Citações Web of Science: 0

Resumo

This work is an innovative study of ordered mesoporous silica (SBA-15) nanocomposites, with different morphologies, and superparamagnetic iron oxide nanoparticles (SPIONs), as promising drug delivery vehicles guided by magnetization. Incorporating SPIONs into SBA-15 is of great interest because it can improve controlled delivery of drugs as well as avoid agglomeration of the nanoparticles. SPIONs were prepared by coprecipitation and thermal decomposition methods and incorporated into SBA-15, with different morphologies, by the incipient wetness impregnation method. The nanocomposites (SBA-15:SPIONs) were characterized by physicochemical techniques, including small-angle X-ray scattering, X-ray diffraction, nitrogen adsorption-desorption isotherms, scanning and transmission electron microscopies, energy-dispersive spectroscopy, magnetization measurements, pair distribution function analysis, Fourier transform infrared spectroscopy, thermogravimetric analysis, and differential thermal analysis. The X-ray diffraction and small-angle X-ray scattering data of the nanocomposites verified that the crystalline phase of magnetite (Fe3O4) and the pore structure of the SBA-15 did not undergo significant changes. N-2 physisorption data evidenced significant changes in the textural properties of the pure SBA-15, indicating the incorporation of SPIONs into the mesopores, with greater incorporation when the nanopartides are obtained by thermal decomposition, in agreement with the small-angle X-ray scattering results. Transmission electron microscopy images, energy-dispersive spectroscopy, and thermogravimetry results evidence the successful incorporation of SPIONs into the silica matrix. The SBA-15:SPIONs presented superparamagnetic behavior. The pair distribution function method revealed a significant variation in the local structure related to changes in the Si-Si-O coordination caused by the decrease in the SBA-15 particle size. The incorporation of SPIONs was better for silica with smaller particle sizes and a higher proportion of SPIONs. Biological assays, such as myelotoxicity and cell viability, demonstrated that the nanocomposites could be safe potential drug delivery vehicles. (AU)

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• Beneficiário: Pedro Leonidas Oseliero Filho
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 14/50869-6 - INCT 2014: em Eletrônica Orgânica INEO
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• Modalidade de apoio: Auxílio à Pesquisa - Temático
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• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
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• Beneficiário: Pedro Leonidas Oseliero Filho
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado