e(III)-Based Layered Double Hydroxides Carrying Model Naproxenate Anions: Compositional and Structural Aspect

Autor(es)

Figueiredo, Mariana Pires ^[1] ; Cunha, Vanessa R. R. ^{[1, 2]} ; Cellier, Joel ^{[3, 4]} ; Taviot-Gueho, Christine ^{[3, 4]} ; Constantino, Vera R. L. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, Av Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP - Brazil

^[2] Inst Fed Educ Ciencia & Tecnol Mato Grosso IFMT, Linha J S-No, BR-78320000 Juina, MT - Brazil

^[3] Univ Clermont Auvergne, BP 10448, F-63000 Clermont Ferrand - France

^[4] Inst Chim Clermont Ferrand, UMR 6296, CNRS, F-63178 Aubiere - France

• Tipo de documento: Artigo Científico
• Fonte: CHEMISTRYSELECT; v. 7, n. 1 JAN 11 2022.
• Citações Web of Science: 0

Resumo

In this work, Al cation was gradually replaced by Fe-III in the composition of Layered Double Hydroxides (LDH) and systematically investigated for LDH application as drug carriers, ultimate aiming to improve their biointegration. The incorporation of Fe-III into LDH layers, as well the intercalation of organic anions in the iron-based materials, is challenging. Several studies approach the intercalation of non-steroidal anti-inflammatory drugs such as anionic naproxen (NAP) into Al-LDH. Thus, NAP was applied here as a model drug for the study of compositional and structural aspects of novel Fe-III-LDH carriers envisaging to shed light on the intercalation of other carboxylate drugs into these materials. LDH of general {[}M2FeyAl(1-y)(OH)(6)]A(n-) compositions (M-II=Mg or Zn; A(n-)=anion of charge n) were investigated using two synthetic methods for NAP intercalation. Full X-ray diffraction profile refinement and a crystal-geometrical reasoning were used to strengthen the results interpretation. Unlike coprecipitation, in which probably NAP complexation with Fe-III hinders LDH-NAP self-assembling, topotactic ion exchange demonstrated to be a potential approach. (AU)

• Processo FAPESP: 16/13862-9 - Concepção e desenvolvimento de nanocarregadores de fármacos base de hidróxidos duplos lamelares
• Beneficiário: Mariana Pires Figueiredo
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 16/50317-9 - Biocompatible nanovectors based on hybrid lamellar materials and composites with polymers for drug release
• Beneficiário: Vera Regina Leopoldo Constantino
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/15900-0 - Síntese e caracterização de hidróxidos duplos lamelares constituídos de metais essenciais para encapsulamento de fármacos
• Beneficiário: Mariana Pires Figueiredo
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 12/12209-9 - Carregadores inorgânicos de substâncias bioativas: desenvolvimento, caracterização, estudos de toxicidade, de liberação in vitro e de absorção in vivo após administração oral
• Beneficiário: Vanessa Roberta Rodrigues da Cunha
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado