| Texto completo | |
| Autor(es): |
Figueiredo, Mariana Pires
[1]
;
Cunha, Vanessa R. R.
[1, 2]
;
Cellier, Joel
[3, 4]
;
Taviot-Gueho, Christine
[3, 4]
;
Constantino, Vera R. L.
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, Av Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP - Brazil
[2] Inst Fed Educ Ciencia & Tecnol Mato Grosso IFMT, Linha J S-No, BR-78320000 Juina, MT - Brazil
[3] Univ Clermont Auvergne, BP 10448, F-63000 Clermont Ferrand - France
[4] Inst Chim Clermont Ferrand, UMR 6296, CNRS, F-63178 Aubiere - France
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CHEMISTRYSELECT; v. 7, n. 1 JAN 11 2022. |
| Citações Web of Science: | 0 |
| Resumo | |
In this work, Al cation was gradually replaced by Fe-III in the composition of Layered Double Hydroxides (LDH) and systematically investigated for LDH application as drug carriers, ultimate aiming to improve their biointegration. The incorporation of Fe-III into LDH layers, as well the intercalation of organic anions in the iron-based materials, is challenging. Several studies approach the intercalation of non-steroidal anti-inflammatory drugs such as anionic naproxen (NAP) into Al-LDH. Thus, NAP was applied here as a model drug for the study of compositional and structural aspects of novel Fe-III-LDH carriers envisaging to shed light on the intercalation of other carboxylate drugs into these materials. LDH of general {[}M2FeyAl(1-y)(OH)(6)]A(n-) compositions (M-II=Mg or Zn; A(n-)=anion of charge n) were investigated using two synthetic methods for NAP intercalation. Full X-ray diffraction profile refinement and a crystal-geometrical reasoning were used to strengthen the results interpretation. Unlike coprecipitation, in which probably NAP complexation with Fe-III hinders LDH-NAP self-assembling, topotactic ion exchange demonstrated to be a potential approach. (AU) | |
| Processo FAPESP: | 16/13862-9 - Concepção e desenvolvimento de nanocarregadores de fármacos base de hidróxidos duplos lamelares |
| Beneficiário: | Mariana Pires Figueiredo |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 16/50317-9 - Biocompatible nanovectors based on hybrid lamellar materials and composites with polymers for drug release |
| Beneficiário: | Vera Regina Leopoldo Constantino |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 14/15900-0 - Síntese e caracterização de hidróxidos duplos lamelares constituídos de metais essenciais para encapsulamento de fármacos |
| Beneficiário: | Mariana Pires Figueiredo |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 12/12209-9 - Carregadores inorgânicos de substâncias bioativas: desenvolvimento, caracterização, estudos de toxicidade, de liberação in vitro e de absorção in vivo após administração oral |
| Beneficiário: | Vanessa Roberta Rodrigues da Cunha |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |