| Texto completo | |
| Autor(es): |
Mendes, Luis Felipe S.
;
Costa-Filho, Antonio J.
Número total de Autores: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | FEBS Letters; v. 596, n. 8, p. 18-pg., 2022-02-14. |
| Resumo | |
The classical secretory pathway is the key membrane-based delivery system in eukaryotic cells. Several families of proteins involved in the secretory pathway, with functionalities going from cargo sorting receptors to the maintenance and dynamics of secretory organelles, share soluble globular domains predicted to mediate protein-protein interactions. One of them is the 'Golgi Dynamics' (GOLD) domain, named after its strong association with the Golgi apparatus. There are many GOLD-containing protein families, such as the transmembrane emp24 domain-containing proteins (TMED/p24 family), animal SEC14-like proteins, human Golgi resident protein ACBD3, a splice variant of TICAM2 called TRAM with GOLD domain, and FYCO1. Here, we critically review the state-of-the-art knowledge of the structures and functions of the main representatives of GOLD-containing proteins in vertebrates. We provide the first unified description of the GOLD domain structure across different families since the first high-resolution structure was determined. With a brand-new update on the definition of the GOLD domain, we also discuss how its tertiary structure fits the beta-sandwich-like fold map and give exciting new directions for forthcoming studies. (AU) | |
| Processo FAPESP: | 17/24669-8 - Desvendando as bases moleculares de processos iniciais da secreção de proteínas em humanos utilizando técnicas biofísicas |
| Beneficiário: | Luis Felipe Santos Mendes |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 20/15542-7 - Construção e caracterização de micro-reatores da proteína clorocatecol 1,2-dioxigenase que utilizam domínios de baixa complexidade como adesivos moleculares |
| Beneficiário: | Antonio José da Costa Filho |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 15/50366-7 - Resolving mechanistic details of peptide transport across membranes using crystallographic and non-crystallographic structural biology approaches |
| Beneficiário: | Antonio José da Costa Filho |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 21/10465-7 - Explorando a dinâmica de agregação/desagregação de uma proteína da matriz de Golgi sob condições de estresse |
| Beneficiário: | Luis Felipe Santos Mendes |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado |