| Texto completo | |
| Autor(es): Mostrar menos - |
Freitas-Dias, Ricardo
;
Lima, Tanes, I
;
Costa-Junior, Jose Maria
;
Goncalves, Luciana M.
;
Araujo, Hygor N.
;
Paula, Flavia M. M.
;
Santos, Gustavo J.
;
Souto Branco, Renato Chaves
;
Ou, Kristy
;
Kaestner, Klaus H.
;
Silveira, Leonardo R.
;
Oliveira, Camila A. M.
;
Boschero, Antonio C.
;
Zoppi, Claudio C.
;
Carneiro, Everardo M.
Número total de Autores: 15
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Life Sciences; v. 291, p. 8-pg., 2022-02-15. |
| Resumo | |
Aim Investigate whether inheritance of improved skeletal muscle mitochondrial function and its association with glycemic control are multigenerational benefits of exercise. Main methods: Male Swiss mice were subjected to 8 weeks of endurance training and mated with untrained females. Key findings: Trained fathers displayed typical endurance training-induced adaptations. Remarkably, offspring from trained fathers also exhibited higher endurance performance, mitochondrial oxygen consumption, glucose tolerance and insulin sensitivity. However, PGC-1 alpha expression was not increased in the offspring. In the offspring, the expression of the co-repressor NCoR1 was reduced, increasing activation of PGC-1 alpha target genes. These ef-fects correlated with higher DNA methylation at the NCoR1 promoter in both, the sperm of trained fathers and in the skeletal muscle of their offspring. Significance: Higher skeletal muscle mitochondrial function is inherited by epigenetic de-activation of a key PGC-1 alpha co-repressor. (AU) | |
| Processo FAPESP: | 15/12611-0 - Mecanismos moleculares envolvidos na disfunção e morte de células beta pancreáticas no Diabetes mellitus: estratégias para a inibição desses processos e para a recuperação da massa insular |
| Beneficiário: | Antonio Carlos Boschiero |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 14/01717-9 - Investigação dos efeitos insulinotrópicos, insulinomiméticos e endoteliais da taurina em células/tecidos submetidos à restrição in vitro de aminoácidos: uma abordagem integrada e multifocal |
| Beneficiário: | Everardo Magalhães Carneiro |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |