Surface Engineering for Dental Implantology: Favoring Tissue Responses Along the Implant

Autor(es)

van Oirschot, Bart A. J. A. ; Zhang, Yang ; Alghamdi, Hamdan S. ; Cordeiro, Jairo M. ; Nagay, Bruna E. ; Barao, Valentim A. R. ; de Avila, Erica Dorigatti ; van den Beucken, Jeroen J. J. P.

• Tipo de documento: Artigo Científico
• Fonte: TISSUE ENGINEERING PART A; v. 28, n. 11-12, p. 18-pg., 2022-06-01.

Resumo

Dental implants represent an illustrative example of successful medical devices used in increasing numbers to aid (partly) edentulous patients. Particularly in spite of the percutaneous nature of dental implant systems, their clinical success is remarkable. This clinical success is at least partly related to the effective surface treatment of the artificial dental root, providing appropriate physicochemical properties to achieve osseointegration. The demographic changes in the world, however, with a rapidly increasing life expectancy and an increase in patients suffering from comorbidities that affect wound healing and bone metabolism, make that the performance of dental implants requires continuous improvement. An additional factor endangering the clinical success of dental implants is peri-implantitis, which affects both the soft and hard tissue interactions with dental implants. In this study, we shed light on the optimization of dental implant surfaces through surface engineering. Depending on the region along the artificial dental root, different properties of the surface are required to optimize prevailing tissue response to facilitate osseointegration, improve soft tissue attachment, and exert antibacterial efficacy. As such, surface engineering represents an important tool for assuring the continued future success of dental implants. Impact StatementDental implants represent a common treatment modality nowadays for the replacement of lost teeth or fixation of prosthetic devices. This review provides a detailed overview of the role of surface engineering for dental implants and their components to optimize tissue responses at the different regions along the artificial dental root. The surface properties steering immunomodulatory processes, facilitating osseointegration, and rendering antibacterial efficacy (at both artificial root and abutment region) are described. The review finally concludes that surface engineering provides a tool to warrant that dental implants will remain future proof in more challenging applications, including an aging patient population and comorbidities that affect bone metabolism and wound healing. (AU)

• Processo FAPESP: 20/05231-4 - Desenvolvimento de um novo hidrogel termosensitivo para liberação controlada de drogas direcionado a prevenção e ao tratamento de inflamações peri-implantares
• Beneficiário: Valentim Adelino Ricardo Barão
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/20719-3 - Um novo revestimento antimicrobiano para liberação de droga direcionado a dispositivos implantares percutâneos
• Beneficiário: Érica Dorigatti de Avila
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 21/09434-0 - Um novo revestimento antimicrobiano para liberação de droga direcionado a dispositivos implantares percutâneos
• Beneficiário: Érica Dorigatti de Avila
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 19/17238-6 - Revestimento antibacteriano com potencial fotocatalítico sob luz visível para implantes dentários: estudos in vitro, in situ e in vivo
• Beneficiário: Bruna Egumi Nagay
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/01320-0 - Desenvolvimento de uma superfície bioativa e antibacteriana contendo Cu2O para implantes dentários
• Beneficiário: Jairo Matozinho Cordeiro
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 15/03567-7 - Modificação das propriedades físico-químicas das superfícies de titânio para abutments de implantes com diferentes tipos de revestimentos e avaliação do efeito do tratamento no desenvolvimento de um complexo biofilme oral: um estudo preliminar in vitro
• Beneficiário: Érica Dorigatti de Avila
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado