State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions

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Lavin, Kaleen M. ; Coen, Paul M. ; Baptista, Liliana C. ; Bell, Margaret B. ; Drummer, Devin ; Harper, Sara A. ; Lixandrao, Manoel E. ; McAdam, Jeremy S. ; O'Bryan, Samia M. ; Ramos, Sofhia ; Roberts, Lisa M. ; Vega, Rick B. ; Goodpaster, Bret H. ; Bamman, Marcas M. ; Buford, Thomas W.

• Tipo de documento: Artigo Científico
• Fonte: COMPREHENSIVE PHYSIOLOGY; v. 12, n. 2, p. 87-pg., 2022-04-01.

Resumo

For centuries, regular exercise has been acknowledged as a potent stimulus to promote, maintain, and restore healthy functioning of nearly every physiological system of the human body. With advancing understanding of the complexity of human physiology, continually evolving method-ological possibilities, and an increasingly dire public health situation, the study of exercise as a preventative or therapeutic treatment has never been more interdisciplinary, or more impactful. During the early stages of the NIH Common Fund Molecular Transducers of Physical Activity Con-sortium (MoTrPAC) Initiative, the field is well-positioned to build substantially upon the existing understanding of the mechanisms underlying benefits associated with exercise. Thus, we present a comprehensive body of the knowledge detailing the current literature basis surrounding the molecular adaptations to exercise in humans to provide a view of the state of the field at this criti-cal juncture, as well as a resource for scientists bringing external expertise to the field of exercise physiology. In reviewing current literature related to molecular and cellular processes underlying exercise-induced benefits and adaptations, we also draw attention to existing knowledge gaps warranting continued research effort. ?? 2022 American Physiological Society. Compr Physiol 12:3193-3279, 2022. (AU)

• Processo FAPESP: 16/22635-6 - Efeito do volume de treinamento de força sobre a variabilidade da hipertrofia muscular em idosos
• Beneficiário: Manoel Emílio Lixandrão
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/15691-2 - Efeito do volume de treinamento de força sobre a variabilidade da hipertrofia muscular em idosos
• Beneficiário: Manoel Emílio Lixandrão
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado