Understanding the role of electrostatic interactions on the association of 5-fluorouracil to chitosan-TPP nanoparticles

Autor(es)

dos Santos, Aline Martins ; Carvalho, Suzana Goncalves ; Barboza Ferreira, Leonardo Miziara ; Chorilli, Marlus ; Daflon Gremiao, Maria Palmira

• Tipo de documento: Artigo Científico
• Fonte: COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS; v. 640, p. 8-pg., 2022-05-05.

Resumo

Judicious design strategies should be considered powerful tools to better control the properties of chitosan (CS) and tripolyphosphate (TPP) particles. This study focused on understanding the role of the charge properties of 5-fluorouracil (5-FU) on the formation and properties of CS-TPP nanoparticles. The effect of synthesis variables of CS-TPP nanoparticles (CS to TPP ratio and order of addition) under pH 4.5 and 5.5 was evaluated, where CS and TPP were charged, and 5-FU had two different charges (positive and negative), maximizing the interactions between them for the formation of nanoparticles. The order of addition and drug location resulted in changes in the interaction forces, influencing the particle size and size distribution. 5-FU addition into CS resulted in stronger interactions, favoring the formation of smaller particles. The pH of reactional medium and CS to TPP ratio affected the properties of particles, in terms of size and potential zeta, which led to greater 5-FU entrap-ment. These results demonstrated that the particle properties still depends of the synthesis factors, but the physicochemical properties of drug also influence the reactions/interactions involved in the formation of CS-TPP nanoparticles. (AU)

• Processo FAPESP: 14/50928-2 - INCT 2014: Nanotecnologia Farmacêutica: uma abordagem transdisciplinar
• Beneficiário: Maria Vitória Lopes Badra Bentley
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/01464-9 - Sistemas multifuncionalizados empregando nanopartículas de quitosana ancoradas com metotrexato e incorporadas em micropartículas baseadas em amido resistente/pectina para liberação cólon-específica do 5-fluorouracil para o tratamento do câncer colorretal
• Beneficiário: Aline Martins dos Santos
• Modalidade de apoio: Bolsas no Brasil - Doutorado