Thermosensitive and Biocompatible Nanocomposites of Poly(N-vinylcaprolactam) and Hydroxyapatite with Potential Use for Bone Tissue Repair

Autor(es)

Assis, Jordanna F. ; Gabriel, Arthur M. ; Goncalves, Leidiane F. ; Machado, Monica R. F. ; Morgado, Daniella L. ; Sala, Renata L. ; Cristovan, Fernando H. ; Oliveira, Mauricio P. ; Arantes, Tatiane M. ; Camargo, Emerson R.

• Tipo de documento: Artigo Científico
• Fonte: BIONANOSCIENCE; v. N/A, p. 8-pg., 2022-06-17.

Resumo

Thermosensitive nanocomposites of poly(N-vinylcaprolactam) and hydroxyapatite nanoparticles synthesized by hydrothermal processing were prepared by in situ polymerization in dimethyl sulfoxide, using azobisisobutyronitrile as a radical initiator. Polymerization was performed in the presence of nanoparticles (1% w/w) at 70 degrees C during 4 h to obtain a new stimuli-responsive biomaterial for medical/dental applications. The biocompatibility of the injectable nanocomposites was verified through the survival ratio and eclosion ratio of zebrafish embryos, which revealed a polymer of low toxicity, showing an average survival ratio of 93% after 96 h of exposition up to 25% of nanocomposites in water. In this sense, this work introduces an injectable hydrogel biomaterial with potential osseointegration properties for bone tissue engineering. (AU)

• Processo FAPESP: 13/07296-2 - CDMF - Centro de Desenvolvimento de Materiais Funcionais
• Beneficiário: Elson Longo da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs