Thermosensitive and Biocompatible Nanocomposites of Poly(N-vinylcaprolactam) and Hydroxyapatite with Potential Use for Bone Tissue Repair

Author(s)

Assis, Jordanna F. ; Gabriel, Arthur M. ; Goncalves, Leidiane F. ; Machado, Monica R. F. ; Morgado, Daniella L. ; Sala, Renata L. ; Cristovan, Fernando H. ; Oliveira, Mauricio P. ; Arantes, Tatiane M. ; Camargo, Emerson R.

• Document type: Journal article
• Source: BIONANOSCIENCE; v. N/A, p. 8-pg., 2022-06-17.

Abstract

Thermosensitive nanocomposites of poly(N-vinylcaprolactam) and hydroxyapatite nanoparticles synthesized by hydrothermal processing were prepared by in situ polymerization in dimethyl sulfoxide, using azobisisobutyronitrile as a radical initiator. Polymerization was performed in the presence of nanoparticles (1% w/w) at 70 degrees C during 4 h to obtain a new stimuli-responsive biomaterial for medical/dental applications. The biocompatibility of the injectable nanocomposites was verified through the survival ratio and eclosion ratio of zebrafish embryos, which revealed a polymer of low toxicity, showing an average survival ratio of 93% after 96 h of exposition up to 25% of nanocomposites in water. In this sense, this work introduces an injectable hydrogel biomaterial with potential osseointegration properties for bone tissue engineering. (AU)

• FAPESP's process: 13/07296-2 - CDMF - Center for the Development of Functional Materials
• Grantee: Elson Longo da Silva
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC