The treatment of many degenerative diseases or trauma injuries can be overcome using biomaterials, such as injectable hydrogels that are applicable for noninvasive surgery and exhibit potential action in the regeneration and repair of living tissues. The poly (N-vinylcaprolactam) (PNVCL) combined with poly (vinyl alcohol) (PVA) forms a biocompatible thermosensitive hydrogel with lower critical solution temperature (LCST) near to the human body temperature. This transition occurs due the change from a hydrophilic soluble state at lower temperature to a hydrophobic agglomerate state when it is heated. In this project, we will prepare a new class of nanocomposite hydrogels combining PNVCL/PVA synthesized by radical copolymerization with mesoporous silica nanofibers obtained by the Stöber method to improve their mechanical properties, and ytterbium trifluoride nanoparticles synthesized by hydrothermal processing to obtain radiopaque materials. Besides ensuring the biocompatibility of these nanocomposites are their use as scaffolds for tissue engineering, we expect to understand the influence of nanoparticles in the LCST and what factors affect the stability of the nanoparticles during the transition between the hydrophilic / hydrophobic phase (AU)
Articles published in Agência FAPESP Newsletter about the research grant:
DE SOUZA NETO, FRANCISCO NUNES;
SALA, RENATA LANG;
FERNANDES, RENAN APARECIDO;
OLIVEIRA XAVIER, TATIELIH PARDIM;
CRUZ, SANDRA ANDREA;
PARANHOS, CAIO MARCIO;
MONTEIRO, DOUGLAS ROBERTO;
BARBOSA, DEBORA BARROS;
BOTAZZO DELBEM, ALBERTO CARLOS;
DE CAMARGO, EMERSON RODRIGUES.
Effect of synthetic colloidal nanoparticles in acrylic resin of dental use.
EUROPEAN POLYMER JOURNAL,
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