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Modification of the temperature transition profile of thermosensitive nanocomposites

Grant number: 18/12871-0
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): October 01, 2018
Effective date (End): February 28, 2022
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Emerson Rodrigues de Camargo
Grantee:Lucas da Silva Ribeiro
Home Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated research grant:13/07296-2 - CDMF - Center for the Development of Functional Materials, AP.CEPID

Abstract

In recent years, research focused on the development of biomaterials, such as injectable hydrogels for use in non-invasive surgeries and with potential use as a means of transportation and controlled drug release, has been intensified. Among them, poly (N-vinylcaprolactam) (PNVCL) may form biocompatible hydrogels with chemical and mechanical properties suitable for use as implants. A promising alternative in the field of biomaterials is the preparation of nanocomposites that associate the properties of the polymers with the mechanical resistance of bioactive ceramics, such as silica nanoparticles. In this way, nanocomposites of thermosensitive polymers of PNVCL with different compositions of SiO2 nanoparticles of different sizes and concentrations will be prepared in this project, seeking to obtain new biomaterials for the transportation and controlled release of drugs. In order to evaluate the morphology, structure and thermal properties of hydrogels, nanoparticles and nanocomposites, scanning and transmission electron microscopy techniques, dynamic light scattering, infrared absorption spectroscopy, Differential Calorimetry Scanning (DSC) and thermogravimetry (TGA). Finally, by UV-vis spectrophotometry, the analysis of the Lower Critical Solubilization Temperature (LCST) from its thermodynamic parameters and the kinetic study of the release of dyes and antibiotics will be carried out. (AU)