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Preparation, characterization and biological evaluation of nitric oxide releasing polymeric biomaterials

Grant number: 17/05029-8
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2017
Effective date (End): December 31, 2020
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Amedea Barozzi Seabra
Grantee:Milena Trevisan Pelegrino
Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil

Abstract

S-nitrosothiols (RSNOs) are an important class of nitric oxide (NO) donors, involved in several biological processes, such as: (i) control of blood vasodilatation, (ii) antioxidant, antitumoral and antimicrobial activities, (iii) promotion and acceleration of wound healing (iv) regeneration of skin, cartilage, mucosa and globe eye tissues. RSNOs act as NO storage in vivo preserving NO physiological activities. Recently, the combination of RSNOs and biomaterials represents a promising strategy to increase the therapeutical efficacy of RSNOs. In this context, the main purpose of this project is the preparation of RSNOs and their incorporation into nanoparticles and biocompatible hydrogels. RSNOs will be incorporated in chitosan nanoparticles, coated with hyaluronic acid, for targeting the NO-releasing nanoparticles to tumour tissues. Chitosan is a biocompatible and biodegradable biopolymer, employed in the synthesis of nanoparticles for controllable and sustainable drug release. The biopolymer hyaluronic acid has been used for coating nanoparticles to tumour targeting purposes. In addition, the project involves the incorporation of either free RSNOs or encapsulated RSNOs into thermosensitive hydrogels composed by Pluronic F-127/chitosan and chitosan based visible light crosslinkable hydrogels for biomedical applications, including skin regeneration. The project involves the preparation and characterization of NO releasing nanoparticles and hydrogels, the evaluation of the NO release profile from the biomaterials, and biological assays to evaluate and investigate the therapeutic actions of the prepared biomaterials. These new materials are expected to have great potential in biomedical applications. (AU)

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Scientific publications (20)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PELEGRINO, M. T.; BALDI, C.; SOUZA, A. C. S.; SEABRA, A. B.; IOP. Cytotoxicity of hyaluronic acid coated chitosan nanoparticles containing nitric oxide donor against cancer cell lines. WAKE CONFERENCE 2021, v. 1323, p. 8-pg., . (16/10347-6, 17/05029-8, 18/13761-3)
PELEGRINO, M. T.; NATIVIDADE, T. R.; GONCALVES, M. C.; NAKAZATO, G.; SEABRA, A. B.; IOP PUBLISHING. Thiolate chitosan nanoparticles capable to delivery nitric oxide: synthesis, characterization and antibacterial potential. Journal of Physics: Conference Series, v. 1953, p. 9-pg., . (18/08194-2, 17/05029-8)
CARMO, GIOVANNA CAMARGO DO; IASTRENSKI, LORENA FELIX; DEBIASI, TATIANE VIEGAS; SILVA, RAFAEL CAETANO DA; GOMES, DIEGO GENUARIO; PELEGRINO, MILENA TREVISAN; BIANCHINI, EDMILSON; STOLF-MOREIRA, RENATA; PIMENTA, JOSE ANTONIO; SEABRA, AMEDEA BAROZZI; et al. Nanoencapsulation improves the protective effects of a nitric oxide donor on drought-stressed Heliocarpus popayanensis seedlings. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, v. 225, . (18/08194-2, 17/05029-8)
KOHATSU, MARCIO YUKIHIRO; PELEGRINO, MILENA TREVISAN; MONTEIRO, LUCILENA REBELO; FREIRE, BRUNA MOREIRA; PEREIRA, RODRIGO MENDES; FINCHEIRA, PAOLA; RUBILAR, OLGA; TORTELLA, GONZALO; BATISTA, BRUNO LEMOS; DE JESUS, TATIANE ARAUJO; et al. Comparison of foliar spray and soil irrigation of biogenic CuO nanoparticles (NPs) on elemental uptake and accumulation in lettuce. APL BIOENGINEERING, v. 5, n. 1, p. 16350-16367, . (19/26337-8, 16/10060-9, 17/05029-8, 17/20914-8, 18/08194-2)
KOHATSU, MARCIO YUKIHIRO; LANGE, CAMILA NEVES; PELEGRINO, MILENA TREVISAN; PIERETTI, JOANA CLAUDIO; TORTELLA, GONZALO; RUBILAR, OLGA; BATISTA, BRUNO LEMOS; SEABRA, AMEDEA BAROZZI; DE JESUS, TATIANE ARAUJO. Foliar spraying of biogenic CuO nanoparticles protects the defence system and photosynthetic pigments of lettuce (Lactuca sativa). JOURNAL OF CLEANER PRODUCTION, v. 324, . (19/26337-8, 17/20914-8, 17/05029-8, 21/00738-6, 18/08194-2, 16/10060-9)
PELEGRINO, MILENA T.; WELLER, RICHARD B.; PAGANOTTI, ANDRE; SEABRA, AMEDEA B.. Delivering nitric oxide into human skin from encapsulated S-nitrosoglutathione under UV light: An in vitro and ex vivo study. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 94, p. 108-113, . (18/08194-2, 17/05029-8)
PELEGRINO, MILENA T.; PIERETTI, JOANA C.; NAKAZATO, GERSON; GONCALVES, MARCELLY CHUE; MOREIRA, JOSE CARLOS; SEABRA, AMEDEA B.. Chitosan chemically modified to deliver nitric oxide with high antibacterial activity. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 106, p. 24-34, . (18/08194-2, 17/05029-8, 18/02832-7)
PELEGRINO, MILENA T.; PAGANOTTI, ANDRE; SEABRA, AMEDEA B.; WELLER, RICHARD B.. Photochemistry of nitric oxide andS-nitrosothiols in human skin. Histochemistry and Cell Biology, v. 153, n. 6, p. 431-441, . (16/10347-6, 17/05029-8)
PELEGRINO, MILENA T.; LIMA, BRUNA DE ARAUJO; DO NASCIMENTO, MONICA H. M.; LOMBELLO, CHRISTIANE B.; BROCCHI, MARCELO; SEABRA, AMEDEA B.. Biocompatible and Antibacterial Nitric Oxide-Releasing Pluronic F-127/Chitosan Hydrogel for Topical Applications. POLYMERS, v. 10, n. 4, . (16/10347-6, 17/05029-8)
CAIO-SILVA, WELLINGTON; DA SILVA DIAS, DANIELLE; JUNHO, CAROLINA VICTORIA CRUZ; PANICO, KARINE; NERES-SANTOS, RAQUEL SILVA; PELEGRINO, MILENA TREVISAN; PIERETTI, JOANA CLAUDIO; SEABRA, AMEDEA BAROZZI; DE ANGELIS, KATIA; CARNEIRO-RAMOS, MARCELA SORELLI. Characterization of the Oxidative Stress in Renal Ischemia/Reperfusion-Induced Cardiorenal Syndrome Type 3. BIOMED RESEARCH INTERNATIONAL, v. 2020, . (18/02832-7, 18/08194-2, 08/10175-4, 17/05029-8, 19/11077-0)
PELEGRINO, MILENA TREVISAN; KOHATSU, MARCIO YUKIHIRO; SEABRA, AMEDEA BAROZZI; MONTEIRO, LUCILENA REBELO; GOMES, DIEGO GENUARIO; OLIVEIRA, HALLEY CAIXETA; ROLIM, WALLACE ROSADO; DE JESUS, TATIANE ARAUJO; BATISTA, BRUNO LEMOS; LANGE, CAMILA NEVES. Effects of copper oxide nanoparticles on growth of lettuce (Lactuca sativa L.) seedlings and possible implications of nitric oxide in their antioxidative defense. ENVIRONMENTAL MONITORING AND ASSESSMENT, v. 192, n. 4, . (18/08194-2, 17/05029-8)
NASCIMENTO, MONICA H. M.; PELEGRINO, MILENA T.; PIERETTI, JOANA C.; SEABRAL, AMEDEA B.. How can nitric oxide help osteogenesis?. AIMS MOLECULAR SCIENCE, v. 7, n. 1, p. 29-48, . (18/08194-2, 17/05029-8, 18/02832-7)
PELEGRINO, MILENA T.; SEABRA, AMEDEA B.. Chitosan-Based Nanomaterials for Skin Regeneration. AIMS MEDICAL SCIENCE, v. 4, n. 3, p. 352-381, . (16/10347-6, 17/05029-8)
LOPES-OLIVEIRA, PATRICIA JULIANA; GOMES, DIEGO GENUARIO; PELEGRINO, MILENA TREVISAN; BIANCHINI, EDMILSON; PIMENTA, JOSE ANTONIO; STOLF-MOREIRA, RENATA; SEABRA, AMEDEA BAROZZI; OLIVEIRA, HALLEY CAIXETA. Effects of nitric oxide-releasing nanoparticles on neotropical tree seedlings submitted to acclimation under full sun in the nursery. SCIENTIFIC REPORTS, v. 9, . (18/08194-2, 17/05029-8)
PIERETTI, JOANA C.; PELEGRINO, MILENA T.; NASCIMENTO, MONICA H. M.; TORTELLA, GONZALO R.; RUBILAR, OLGA; SEABRA, AMEDEA B.. Small molecules for great solutions: Can nitric oxide-releasing nanomaterials overcome drug resistance in chemotherapy?. Biochemical Pharmacology, v. 176, n. SI, . (18/08194-2, 17/05029-8, 18/02832-7)
PISSOLATO, MARIA DOLORES; SILVEIRA, NEIDIQUELE MARIA; PRATAVIERA, PAULA JOYCE CARRENHO; MACHADO, EDUARDO CARUSO; SEABRA, AMEDEA BAROZZI; PELEGRINO, MILENA TREVISAN; SODEK, LADASLAV; RIBEIRO, RAFAEL V.. Enhanced Nitric Oxide Synthesis Through Nitrate Supply Improves Drought Tolerance of Sugarcane Plants. FRONTIERS IN PLANT SCIENCE, v. 11, . (18/08194-2, 17/11279-7, 17/05029-8)
LOURENCO, I. M.; PELEGRINO, M. T.; PIERETTI, J. C.; ANDRADE, G. P.; CERCHIARO, G.; SEABRA, A. B.; IOP. Synthesis, characterization and cytotoxicity of chitosan-coated Fe3O4 nanoparticles functionalized with ascorbic acid for biomedical applications. WAKE CONFERENCE 2021, v. 1323, p. 10-pg., . (18/02832-7, 16/10347-6, 18/13761-3, 16/09652-9, 17/05029-8)
PIERETTI, JOANA C.; PELEGRINO, MILENA T.; NASCIMENTO, MONICA H. M.; TORTELLA, GONZALO R.; RUBILAR, OLGA; SEABRA, AMEDEA B.. Small molecules for great solutions: Can nitric oxide-releasing nanomaterials overcome drug resistance in chemotherapy?. Biochemical Pharmacology, v. 176, p. 13-pg., . (18/08194-2, 18/02832-7, 17/05029-8)
GOMES, DIEGO G.; PELEGRINO, MILENA T.; FERREIRA, ANDRE S.; BAZZO, JOSE H. B.; ZUCARELI, CLAUDEMIR; SEABRA, AMEDEA B.; OLIVEIRA, HALLEY C.. Seed priming with copper-loaded chitosan nanoparticles promotes early growth and enzymatic antioxidant defense of maize (Zea mays L.) seedlings. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, v. 96, n. 8, p. 2176-2184, . (18/08194-2, 17/05029-8)
KOHATSU, MARCIO YUKIHIRO; PELEGRINO, MILENA TREVISAN; MONTEIRO, LUCILENA REBELO; FREIRE, BRUNA MOREIRA; PEREIRA, RODRIGO MENDES; FINCHEIRA, PAOLA; RUBILAR, OLGA; TORTELLA, GONZALO; BATISTA, BRUNO LEMOS; DE JESUS, TATIANE ARAUJO; et al. Comparison of foliar spray and soil irrigation of biogenic CuO nanoparticles (NPs) on elemental uptake and accumulation in lettuce. Environmental Science and Pollution Research, v. 28, n. 13, p. 16350-16367, . (17/05029-8, 19/26337-8, 16/10060-9, 17/20914-8, 18/08194-2)

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Filed patent(s) as a result of this research project

NANOPARTÍCULAS DE QUITOSANA CONTENDO ÁCIDO S-NITROSO-MERCAPTOSUCCÍNICO (S-NITROSO-MSA) PARA TRATAMENTO DE LEISHMANIOSE CUTÂNEA BR1020180002325 - Universidade Federal do ABC (UFABC) . AMEDEA BAROZZI SEABRA / MARTHA SIMÕES RIBEIRO / RONEI MIOTTO / FERNANDA VIANA CABRAL / MILENA TREVISAN PELEGRINO - January 2018, 04