Bone diseases, such as osteoporosis and osteoarthritis, have become relevant to public health due to the growing number of cases. A possible treatment is the use of the flavonoid naringin, which has pro-osteogenic properties. However, this drug is rapidly metabolized by the body, which reduces its clinical performance. As a solution, they can be applied to the body through controlled release systems. In this context, formulations based on the thermosensitive polymer poly (N-vinylcaprolactam) (PNVCL), which is soluble at room temperature, but at physiological temperature, becomes a hydrogel. Thus, in this research project, nanocomposites will be prepared by in situ polymerization of the PNVCL in the presence of mesoporous nanospheres of silica , in order to obtain biocompatible hydrogels that are able to act in the treatment of bone diseases. The nanospheres will act in this system as a second control mechanism of release. After previous investigation of the structural, morphological and thermal properties of nanocomposites in Brazil, the in vitro evaluation of the biocompatibility and biodegradability of these materials, in addition to their ability to release naringin in a controlled manner for the pro-osteogenic differentiation of cells, will be carried out at University of Aveiro.
News published in Agência FAPESP Newsletter about the scholarship: