Development of novel magnetic nanocomposites based on hydrogel for evaluation as carrier vehicle of drugs and agricultural inputs

• Grant number: 18/18697-1
• Support Opportunities: Regular Research Grants
• Duration: February 01, 2021 - July 31, 2023
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
• Principal Investigator: Fauze Ahmad Aouada
• Grantee: Fauze Ahmad Aouada
• Host Institution: Faculdade de Engenharia (FEIS). Universidade Estadual Paulista (UNESP). Campus de Ilha Solteira. Ilha Solteira , SP, Brazil
• Associated researchers: Márcia Regina de Moura Aouada ; Renato Grillo

Abstract

With the advances of the world technology, the use of conventional methods in agribusiness is decreasing due to the increase of the use of precision agriculture that appears as a modern mechanism, reflecting a new model of productivity together with environment qualification. Linked to precision agriculture, it can be highlighted in the development of biodegradable hydrogels and their nanocomposites as carrier vehicles for controlled release. In parallel, the economy suffers with high cost of inputs used in the medical area. In this way, biomaterials with less cost have been developed. In addition, by the fact of the drugs need of continuous administration, the conventional methods are no most appropriated for application to patients, whereas that these methods have many collateral effects. In this way, the substitution of these methods by controlled release technology opens new perspectives because when the drugs are applied from conventional methods, their release presents a maximum dosage peak losing this effect, reaching an inefficient level. In this sense, the key innovation of this project is to obtain and characterize of hybrid nanocomposites with iron oxide nanoparticles, and to modify nanostructures, such as nanoclay. Aiming their magnetic properties for application in controlled release of agricultural inputs with reuse possibility and in the medical area as carrier vehicle for the drug controlled release with remote activation. The project has as global objective continue the research, partially funded by this agency, related to the synthesis, characterization, and development of nanocomposites based on polysaccharide and inorganic materials as nanoclay and zeolite for agriculture application. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERNANDES, RENAN DA SILVA; TANAKA, FABRICIO CERIZZA; FERREIRA JUNIOR, CARLOS ROBERTO; YONEZAWA, UILIAN GABALDI; DE MOURA, MARCIA REGINA; AOUADA, FAUZE AHMAD. PAAm/CMC/nanoclay nanocomposite hydrogel: understanding the influence of initiators on the chain-growth mechanisms. JOURNAL OF POLYMER RESEARCH, v. 29, n. 12, p. 12-pg., 2022-12-01. (13/03643-0, 13/07296-2, 18/18697-1)

ALVES, BRUNO C.; MIRANDA, RENATO DE S.; FRIGIERI, BARBARA M.; ZUCCARI, DEBORA A. P. C.; DE MOURA, MARCIA R.; AOUADA, FAUZE A.; TOKIMATSU, RUIS C.. A 3D Printing Scaffold Using Alginate/Hydroxyapatite for Application in Bone Regeneration. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 26, p. 7-pg., 2023-01-01. (13/03643-0, 13/07296-2, 18/18697-1)

WATANUKI FILHO, ADHEMAR; HIGUTI, RICARDO TOKIO; DE MOURA, MARCIA REGINA; AOUADA, FAUZE AHMAD. Synthesis, Application and Effect of Hybrid Nanocomposites Based on Hydrogel and Nanoclay in Cement-Mortars. POLYMERS, v. 14, n. 21, p. 23-pg., 2022-11-01. (18/18697-1, 18/13580-9, 13/07296-2)

DE LIMA, PEDRO HENRIQUE CORREIA; TAVARES, ALBANIZA ALVES; SILVA, SUEDINA MARIA DE LIMA; DE MOURA, MARCIA REGINA; AOUADA, FAUZE AHMAD; GRILLO, RENATO. Recent advances on nanohybrid systems constituting clay-chitosan with organic molecules-A review. APPLIED CLAY SCIENCE, v. 226, p. 14-pg., 2022-09-01. (19/06170-1, 18/18697-1)

M. A. F. CALESCO; A. WATANUKI FILHO; M. R. DE MOURA; F. A. AOUADA. Efeitos da adição de nanocompósito híbrido baseado em hidrogel de polissacarídeo e nanoargila nas propriedades nos estados fresco e endurecido de argamassas cimentícias. Cerâmica, v. 68, n. 385, p. 97-107, 2022-03-11. (13/03643-0, 18/18697-1, 18/13580-9, 13/07296-2)

WATANUKI FILHO, ADHEMAR; YONEZAWA, UILIAN GABALDI; DE MOURA, MARCIA REGINA; AOUADA, FAUZE AHMAD. Physicochemical Properties of Hybrid Biodegradable Silica-Hydrogel Composites. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 26, p. 9-pg., 2023-01-01. (13/03643-0, 13/07296-2, 18/18697-1)