Autor(es)

Melges Pejon, Taciane Maria ; Faria, Vinicius Silva ; Gobatto, Claudio Alexandre ; Manchado-Gobatto, Fulvia Barros ; Menezes Scariot, Pedro Paulo ; Cornachione, Anabelle Silva ; Beck, Wladimir Rafael

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF SPORTS MEDICINE; v. N/A, p. 10-pg., 2022-02-18.

Resumo

Metabolic diseases are associated with hypoestrogenism owing to their lower energy expenditure and consequent imbalance. Physical training promotes energy expenditure through PGC-1 alpha and NRF-1, which are muscle proteins of the oxidative metabolism. However, the influence of physical training on protein expression in individuals with hypoestrogenism remains uncertain. Thus, the aim of this study is to determine the effect of 12 weeks of moderate-intensity swimming training on the muscle expression of PGC-1 alpha, NRF-1, glycogen and triglyceride in ovariectomised rats. OVX and OVX+TR rats were subjected to ovariectomy. The trained animals swam for 30 minutes, 5 days/week, at 80% of the critical load intensity. Soleus was collected to quantify PGC-1 alpha and NRF-1 expressions, while gastrocnemius and gluteus maximus were collected to measure glycogen and triglyceride. Blood glucose was also evaluated. Whereas ovariectomy decreased PGC-1 alpha expression (p<0.05) without altering NRF-1 (p=0.48), physical training increased PGC-1 alpha (p<0.01) and NRF-1 (p<0.05). Ovariectomy reduced glycogen (p<0.05) and triglyceride (p<0.05), whereas physical training increased glycogen (p<0.05) but did not change triglyceride (p=0.06). Ovariectomy increased blood glucose (p<0.01), while physical training reduced it (p<0.01). In summary, 12 weeks of individualized and moderate-intensity training were capable of preventing muscle metabolic consequences caused by ovariectomy. (AU)

• Processo FAPESP: 14/50256-4 - Aquisição de sistema de densitometria óssea, sistema de microarranjo tecidual, leitor de placa e termociclador em tempo real para estudo da matriz extracelular
• Beneficiário: Heloisa Sobreiro Selistre de Araújo
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários
• Processo FAPESP: 19/08148-3 - Melatonina e performance física: da ergogenia à aceleração do reparo músculo esquelético pós dano induzido por exercício físico
• Beneficiário: Wladimir Rafael Beck
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/21621-3 - Efeito do treino tarefa específica sobre adaptação muscular em gerbilos pós-acidente vascular encefálico isquêmico
• Beneficiário: Thiago Luiz de Russo
• Modalidade de apoio: Auxílio à Pesquisa - Regular