Recent advances in the design of antimicrobial peptide conjugates

Autor(es)

Silva, Amanda R. P. ; Guimaraes, Marina S. ; Rabelo, Jheniffer ; Herrera Belen, Lisandra ; Jose Perecin, Caio ; Farias, Jorge G. ; Santos, Joao H. P. M. ; Rangel-Yagui, Carlota O.

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF MATERIALS CHEMISTRY B; v. 10, n. 19, p. 15-pg., 2022-02-22.

Resumo

Antimicrobial peptides (AMPs) are ubiquitous host defense peptides characterized by their antibiotic activity and lower propensity for developing resistance compared to classic antibiotics. While several AMPs have shown activity against antibiotic-sensitive and even multi-drug resistant strains, some bottlenecks to further development and clinical applications are still present, for instance, low antimicrobial activity, instability under physiological conditions, systemic toxicity and the potential for compromising the innate host defense immunity. Conjugation to molecules such as proteins, synthetic polymers, small molecules and nanoparticles are strategies under investigation to boost the therapeutic efficacy of AMPs. This review focuses on the design and application of AMPs' conjugates. In silico tools for creating new AMPs and AMPs' conjugates and their clinical development are also discussed. Furthermore, key future considerations regarding the major achievements and challenges of AMPs' conjugates in the antimicrobial resistance context are presented as a take-home message. (AU)

• Processo FAPESP: 18/25994-2 - Desenvolvimento de novas plataformas de PEGuilação de proteínas com potencial terapêutico com recurso à microfluídica
• Beneficiário: João Henrique Picado Madalena Santos
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado