| Texto completo | |
| Autor(es): |
Fernanda Andrade Macaferri da Fonseca
[1]
;
Aline Paulino Espósito
;
Maria Helena Baptista Nunes da Silva
[3]
;
Valéria Sutti Nunes
[4]
;
Patricia Miralda Cazita
[5]
;
Guilherme Silva Ferreira
[6]
;
Maria Esther Jurfest Rivero Ceccon
[7]
;
Werther Brunow de Carvalho
[8]
;
Magda Carneiro-Sampaio
[9]
;
Patricia Palmeira
Número total de Autores: 10
|
| Afiliação do(s) autor(es): | [1] Universidade de Sao Paulo. Faculdade de Medicina FMUSP. Departamento de Pediatria - Brasil
[3] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas - Brasil
[4] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas - Brasil
[5] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas - Brasil
[6] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas - Brasil
[7] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas - Brasil
[8] Universidade de Sao Paulo. Faculdade de Medicina FMUSP. Departamento de Pediatria - Brasil
[9] Universidade de Sao Paulo. Faculdade de Medicina FMUSP. Departamento de Pediatria - Brasil
Número total de Afiliações: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Clinics; v. 77, 2023-01-09. |
| Resumo | |
Abstract Background The association between lipoprotein levels and late-onset neonatal sepsis has shown controversial results. The aims are to assess lipid profile, cytokines, and Monocyte-to-HDL (M/H) ratio as diagnostic and prognostic markers for late-onset neonatal sepsis. Methods This prospective study included 49 septic neonates and 17 controls. Cholesterol (CT), Triglyceride (TG), Very-Low-Density (VLDLc), Low-Density (LDLc), and High-Density Lipoproteins (HDLc) were measured at admission (D0) and on days 3, 7 and 10 to evaluate septic shock outcomes. Cytokines and monocytes were evaluated by flow cytometry. Results Septic newborns showed higher IL-6 and IL-8 at D0 and CT levels on D7 and on D10, which also presented higher TG, VLDLc and non-HDL cholesterol concentrations than controls. The septic shock group (n = 22) revealed a higher number of male subjects, CRP, IL-6, IL-8 and IL-10 levels, while lower TG, HDLc, monocyte numbers and M/H ratio at admission compared to the non-shock group (n = 27). M/H ratio and non-HDL cholesterol on D0 were risk factors for septic shock (OR = 0.70, 0.49‒0.99; OR = 0.96, 0.92‒0.99, respectively). Decreasing levels from D0 to D3 of CT (OR = 0.96, 0.93‒0.99), VLDLc (OR = 0.91, 0.85‒0.98), and non-HDL cholesterol (OR = 0.92, 0.87‒0.98) were also predictors of septic shock. Conclusions Lower M/H ratios and non-HDL cholesterol at admission and decreasing levels of cholesterol, VLDLc and non-HDL cholesterol during a hospital stay are associated with the development of septic shock in newborns with late-onset neonatal sepsis. (AU) | |
| Processo FAPESP: | 16/06887-5 - Estudo de biomarcadores proteicos e perfil de expressão gênica da via do nf-b na sepse neonatal tardia: valor potencial no diagnóstico e prognóstico |
| Beneficiário: | Patricia Palmeira Daenekas Jorge |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |