| Texto completo | |
| Autor(es): |
Anjos, Nicolas S.
;
Chapina, Agata I.
;
Santos, Ana R.
;
Licence, Peter
;
Longo, Luiz S., Jr.
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY; v. 2022, n. 40, p. 8-pg., 2022-10-01. |
| Resumo | |
In the present work, the use of Br phi nsted acidic ionic liquids (BAIL) as catalysts for Groebke-Blackburn-Bienayme (GBB) multicomponent reactions was systematically investigated. A series of four 1-(butyl-4-sulfonic)-3-methylimidazolium salts bearing different anions was easily prepared and screened as acidic catalysts for this transformation. The best reaction conditions were stablished as 20 mol % of catalyst [(SO3H)(4)C(4)C(1)Im][OTf] in refluxing EtOH or MeOH under conventional heating and in sealed tube at 150 degrees C for 1-4 hours under microwave heating, affording a series of imidazo-fused heterocycles in moderate to excellent yields (42-93 %). The homogeneous BAIL catalyst could be recycled and reused in four consecutive reaction cycles, despite of a laborious recovery procedure employed. This approach represents the first example of a task-specific reusable homogeneous Br phi nsted acidic catalyst in GBB reactions and opens new opportunities for the exploration of acidic ionic liquid phases as catalysts for this fascinating multicomponent reaction. (AU) | |
| Processo FAPESP: | 17/06628-2 - Reação de Groebke-Blackburn-Bienaymé Catalisada por Líquidos Iônicos Ácidos para a Obtenção de Imidazo[2,1-b]tiazóis |
| Beneficiário: | Nicolas Santos dos Anjos |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 18/15038-7 - O desenvolvimento tumoral sob a ótica da sinalização celular redox: modulação temporal da produção de óxido nítrico e espécies reativas de oxigênio |
| Beneficiário: | Hugo Pequeno Monteiro |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 19/01314-5 - Imobilização de ácidos de lewis em fases de líquido iônico suportado em polímero: um estudo por espectroscopia de fotoelétrons excitados por raios x |
| Beneficiário: | Luiz Sidney Longo Junior |
| Modalidade de apoio: | Bolsas no Exterior - Pesquisa |