Arboviral Infections in Neurological Disorders in Hospitalized Patients in Sao Jose do Rio Preto, Sao Paulo, Brazil

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Milhim, Bruno H. G. A. ; da Rocha, Leonardo C. ; Terzian, Ana C. B. ; Mazaro, Carolina C. P. ; Augusto, Marcos T. ; Luchs, Adriana ; Zini, Nathalia ; Sacchetto, Livia ; dos Santos, Barbara F. ; Garcia, Pedro H. C. ; Rocha, Rodrigo S. ; Liso, Elisabete ; Brienze, Vania M. S. ; da Silva, Gislaine C. D. ; Vasilakis, Nikos ; Estofolete, Cassia F. ; Nogueira, Mauricio L.

• Tipo de documento: Artigo Científico
• Fonte: Viruses-Basel; v. 14, n. 7, p. 12-pg., 2022-07-01.

Resumo

Arbovirus infections are increasingly important causes of disease, whose spectrum of neurological manifestations are not fully known. This study sought to retrospectively assess the incidence of arboviruses in cerebrospinal fluid samples of patients with neurological symptoms to inform diagnosis of central and peripheral nervous system disorders. A total of 255 cerebrospinal fluid (CSF) samples collected from January 2016 to December 2017 were tested for dengue virus (DENV 1-4), Zika virus (ZIKV), and Chikungunya virus (CHIKV) in addition to other neurotropic arboviruses of interest, using genetic and serologic assays. Of the 255 CSF samples analyzed, 3.53% (09/255) were positive for arboviruses presenting mainly as meningitis, encephalitis, and cerebrovascular events, of which ZIKV was detected in 2.74% (7/255), DENV in 0.78% (2/255), in addition to an identified ILHV infection that was described previously. All the cases were detected in adults aged 18 to 74 years old. Our findings highlight the scientific and clinical importance of neurological syndromes associated with arboviruses and demonstrate the relevance of specific laboratory methods to achieve accurate diagnoses as well as highlight the true dimension of these diseases to ultimately improve public health planning and medical case management. (AU)

• Processo FAPESP: 15/12295-0 - Diagnóstico de arboviroses brasileiras e emergentes em pacientes e mosquitos em duas regiões distintas do Brasil
• Beneficiário: Ana Carolina Bernardes Terzian
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/21719-3 - Estudo epidemiológico da dengue (sorotipos 1 a 4) em coorte prospectiva de São José do Rio Preto, São Paulo, Brasil, durante 2014 a 2018
• Beneficiário: Maurício Lacerda Nogueira
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/15021-1 - Estudo clínico-epidemiológico em coorte prospectiva de gestantes infectadas pelo vírus Zika em São José do Rio Preto
• Beneficiário: Maurício Lacerda Nogueira
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisa em Políticas Públicas para o SUS