Neuropathology of depression in non-demented older adults: A large postmortem study of 741 individuals

Autor(es)

Nunes, Paula Villela ; Suemoto, Claudia Kimie ; Rodriguez, Roberta Diehl ; Leite, Renata Elaine Paraizo ; Nascimento, Camila ; Pasqualucci, Carlos Augusto ; Nitrini, Ricardo ; Jacob-Filho, Wilson ; Grinberg, Lea T. ; Lafer, Beny

• Tipo de documento: Artigo Científico
• Fonte: NEUROBIOLOGY OF AGING; v. 117, p. 10-pg., 2022-06-13.

Resumo

Associations between age-related neuropathological lesions and adult-onset lifetime major depressive disorder (a-MDD), late-life MDD (LLD), or depressive symptoms close to death (DS) were examined in a large community sample of non-demented older adults. Seven hundred forty-one individuals (age at death = 72.2 +/- 11.7 years) from the Biobank for Aging Studies were analyzed. a-MDD was present in 54 (7.3%) participants, LLD in 80 (10.8%), and DS in 168 (22.7%). After adjustment for covariates and compared to controls, a-MDD, LDD and DS were associated with small vessel disease ( p = 0.039, p = 0.003, and p = 0.003 respectively); LLD, and DS were associated with brain infarcts ( p = 0.012, p = 0.018, respectively) and Lewy body disease ( p = 0.043, p = 0.002, respectively). DS was associated with betaamyloid plaque burden ( p = 0.027) and cerebral amyloid angiopathy ( p = 0.035) in cognitively normal individuals (Clinical Dementia Rating scale = 0). Vascular brain pathology was the strongest correlate of clinical depictions of depression in the absence of dementia, corroborating the vascular hypothesis of depression. Lewy body pathology underlay DS. An older adult with DS or LLD should be monitored for possible cognitive decline or neurodegenerative disorders.(c) 2022 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 16/24326-0 - Caracterização da astrogliopatia por tau no envelhecimento e em doenças neurodegenerativas
• Beneficiário: Roberta Diehl Rodriguez
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/07089-8 - Investigação da proteína TDP-43 como neuromarcador do Transtorno Bipolar
• Beneficiário: Camila Nascimento Mantelli
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/16626-0 - Estudo das causas de mortalidade entre os diferentes tipos de demência em uma amostra de comunidade submetida a autópsia e análise anatomopatológica cerebral
• Beneficiário: Beatriz Astolfi Neves
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica