| Texto completo | |
| Autor(es): |
Martins, Isabelle C. V. S.
;
Maciel, Michel G.
;
do Nascimento, Jose L. M.
;
Mafra, Denise
;
Santos, Alexsandro F.
;
Padilha, Camila S.
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | European Journal of Clinical Nutrition; v. N/A, p. 9-pg., 2022-07-12. |
| Resumo | |
The aim of this systematic review and meta-analysis was to evaluate the effects of anthocyanins-interventions on oxidative stress, inflammation, and lipid profile in patients undergoing hemodialysis. This systematic review and meta-analysis were registered on the International Prospective Register of Systematic Reviews (PROSPERO CRD42020209742). The primary outcome was anthocyanins-rich intervention on OS parameters and secondary outcome was anthocyanins-rich intervention on inflammation and dyslipidemia. RevMan 5.4 software was used to analyze the effect size of anthocyanins-rich intervention on OS, inflammation and dyslipidemia. Meta-analysis effect size calculations incorporated random-effects model for both outcomes 1 and 2. Eight studies were included in the systematic review (trials enrolling 715 patients; 165 men and 195 women; age range between 30 and 79 years). Anthocyanin intervention in patients undergoing hemodialysis decrease the oxidant parameters (std. mean: -2.64, 95% CI: [-3.77, -1.50], P <= 0.0001, I-2 = 97%). Specially by reduction of malondialdehyde products in favor of anthocyanins-rich intervention (std. mean: -14.58 mu mol.L, 95% CI: [-26.20, -2.96], P <= 0.0001, I-2 = 99%) and myeloperoxidase (std. mean: -1.28 eta g.mL, 95% CI: [-2.11, -0.45], P = 0.003, I-2 = 77%) against placebo group. Decrease inflammatory parameters (std. mean: -0.57, 95% CI: [-0.98, -0.16], P = 0.007, I-2 = 79%), increase HDL cholesterol levels (std. mean: 0.58 mg.dL, 95% CI: [0.23, 0.94], P = 0.001, I-2 = 12%) against placebo group. Anthocyanins-rich intervention seems to reduce oxidative stress, inflammatory parameters and improve lipid profile by increasing HDL cholesterol levels in patients with chronic kidney disease undergoing hemodialysis. (AU) | |
| Processo FAPESP: | 18/23402-0 - Respostas dos linfócitos T e aptidão cardiorrespiratória em adultos: Papel do tecido adiposo visceral e via de sinalização mTORC1 e mTORC2 |
| Beneficiário: | Camila de Souza Padilha |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |