The oldest unvaccinated Covid-19 survivors in South America

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de Castro, Mateus, V ; Silva, Monize V. R. ; Naslavsky, Michel S. ; Scliar, Marilia O. ; Nunes, Kelly ; Passos-Bueno, Maria Rita ; Castelli, Erick C. ; Magawa, Jhosiene Y. ; Adami, Flavia L. ; Moretti, Ana I. S. ; de Oliveira, Vivian L. ; Boscardin, Silvia B. ; Cunha-Neto, Edecio ; Kalil, Jorge ; Jouanguy, Emmanuelle ; Bastard, Paul ; Casanova, Jean-Laurent ; Quinones-Vega, Mauricio ; Sosa-Acosta, Patricia ; de Guedes, Jessica S. ; de Almeida, Natalia P. ; Nogueira, Fabio C. S. ; Domont, Gilberto B. ; Santos, Keity S. ; Zatz, Mayana

• Tipo de documento: Artigo Científico
• Fonte: IMMUNITY & AGEING; v. 19, n. 1, p. 9-pg., 2022-11-16.

Resumo

Background Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied three Brazilian supercentenarians, older than 110 years, who survived Covid-19 in 2020 before being vaccinated. Results Despite their advanced age, humoral immune response analysis showed that these individuals displayed robust levels of IgG and neutralizing antibodies (NAbs) against SARS-CoV-2. Enrichment of plasma proteins and metabolites related to innate immune response and host defense was also observed. None presented autoantibodies (auto-Abs) to type I interferon (IFN). Furthermore, these supercentenarians do not carry rare variants in genes underlying the known inborn errors of immunity, including particular inborn errors of type I IFN. Conclusion These observations suggest that their Covid-19 resilience might be a combination of their genetic background and their innate and adaptive immunity. (AU)

• Processo FAPESP: 14/50890-5 - INCT 2014: Investigação em Imunologia
• Beneficiário: Jorge Elias Kalil Filho
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/19223-0 - Análise da variabilidade e estrutura haplotípica dos genes KIR2DL4, KIR3DL2, KIR3DL3, LILRB1(ILT2) e LILRB2 (ILT4) em uma amostra brasileira do estado de São Paulo
• Beneficiário: Erick da Cruz Castelli
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/50931-3 - INCT 2014 - Envelhecimento e Doenças Genéticas: Genômica e Metagenômica
• Beneficiário: Mayana Zatz
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/08028-1 - CEGH-CEL - Centro de Estudos do Genoma Humano e de Células-Tronco
• Beneficiário: Mayana Zatz
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs