Busca avançada
Ano de início
Entree


GABAergic CA1 neurons are more stable following context changes than glutamatergic cells

Texto completo
Autor(es):
Schuette, Peter J. ; Ikebara, Juliane M. ; Maesta-Pereira, Sandra ; Torossian, Anita ; Sethi, Ekayana ; Kihara, Alexandre H. ; Kao, Jonathan C. ; Reis, Fernando M. C., V ; Adhikari, Avishek
Número total de Autores: 9
Tipo de documento: Artigo Científico
Fonte: SCIENTIFIC REPORTS; v. 12, n. 1, p. 18-pg., 2022-06-20.
Resumo

The CA1 region of the hippocampus contains both glutamatergic pyramidal cells and GABAergic interneurons. Numerous reports have characterized glutamatergic CAMK2A cell activity, showing how these cells respond to environmental changes such as local cue rotation and context re-sizing. Additionally, the long-term stability of spatial encoding and turnover of these cells across days is also well-characterized. In contrast, these classic hippocampal experiments have never been conducted with CA1 GABAergic cells. Here, we use chronic calcium imaging of male and female mice to compare the neural activity of VGAT and CAMK2A cells during exploration of unaltered environments and also during exposure to contexts before and after rotating and changing the length of the context across multiple recording days. Intriguingly, compared to CAMK2A cells, VGAT cells showed decreased remapping induced by environmental changes, such as context rotations and contextual length resizing. However, GABAergic neurons were also less likely than glutamatergic neurons to remain active and exhibit consistent place coding across recording days. Interestingly, despite showing significant spatial remapping across days, GABAergic cells had stable speed encoding between days. Thus, compared to glutamatergic cells, spatial encoding of GABAergic cells is more stable during within-session environmental perturbations, but is less stable across days. These insights may be crucial in accurately modeling the features and constraints of hippocampal dynamics in spatial coding. (AU)

Processo FAPESP: 16/17329-3 - Caracterização da população de interneurônios e da atividade eletrofisiológica in vivo cortical e hipocampal de ratos adultos submetidos à anóxia neonatal
Beneficiário:Juliane Midori Ikebara
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 17/08668-1 - Estudo in vivo de populações neuronais GABAérgicas e glutamatérgicas da substância cinzenta periaquedutal em resposta a diferentes tipos de ameaça
Beneficiário:Fernando Midea Cuccovia Vasconcelos Reis
Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
Processo FAPESP: 19/17677-0 - Efeitos da anóxia neonatal na memória espacial e atividade das células de lugar em roedores adultos
Beneficiário:Juliane Midori Ikebara
Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
Processo FAPESP: 19/17892-8 - Degeneração e desenvolvimento do sistema nervoso: o papel de processos epigenéticos
Beneficiário:Alexandre Hiroaki Kihara
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/23092-3 - Investigação das vias de sinalização envolvidas na formação da memória de medo em animais expostos ao predador
Beneficiário:Fernando Midea Cuccovia Vasconcelos Reis
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado