A novel strategy for glioblastoma treatment combining alpha-cyano-4-hydroxycinnamic acid with cetuximab using nanotechnology-based delivery systems

Autor(es)

Ferreira, Natalia N. ; Granja, Sara ; Boni, Fernanda Isadora ; Ferreira, Leonardo M. B. ; Reis, Rui M. ; Baltazar, Fatima ; Gremiao, Maria Palmira D.

• Tipo de documento: Artigo Científico
• Fonte: DRUG DELIVERY AND TRANSLATIONAL RESEARCH; v. 10, n. 3, p. 16-pg., 2020-01-24.

Resumo

Combination therapy that uses multiple drugs against different molecular targets should be considered as interesting alternatives for treating complex diseases such as glioblastoma (GBM). Drugs like alpha-cyano-4-hydroxycinnamic acid (CHC) and the monoclonal antibody cetuximab (CTX) are already explored for their capacity to act against different hallmarks of cancer. Previous reports suggest that the simultaneous use of these drugs, as a novel combining approach, might result in additive or synergistic effects. Therefore, advances in nanotechnology-based delivery systems will inevitably bring nano-mediated therapeutic gains to the proposed combination since they enable the association of different drugs into a single carrier. The current study provides indications that the new dual therapeutic strategy proposed, in association with nanotechnology, provides significative improvements when compared to the use of isolated drugs. Nanotechnological tools were employed by developing polymeric nanoparticles based on poly(lactic-co-glycolic acid) and chitosan for CHC encapsulation. Furthermore, these structures were conjugated with CTX by supramolecular forces. In summary, the encapsulation of the CHC drug into the nanoparticles increased its individual therapeutic capacity. In addition, conjugation with CTX seemed to enhance therapeutic efficacy, especially for U251 GBM cells. In conclusion, developed nanostructured delivery systems exhibited a set of favorable attributes and potential to be applied as a promising new alternative for GBM treatment. (AU)

• Processo FAPESP: 18/04546-1 - Avaliação do efeito sinérgico do CHC e cetuximabe no tratamento de glioblastoma utilizando sistemas de liberação
• Beneficiário: Natália Noronha Ferreira Naddeo
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 17/16324-0 - Sistemas com propriedades mucoadesivas para a liberação de fármacos na mucosa intestinal
• Beneficiário: Maria Palmira Daflon Gremião
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/09671-3 - Sistemas multifuncionais nanoestruturados para a liberação de fármacos administrados por via nasal no tratamento de glioblastomas
• Beneficiário: Natália Noronha Ferreira Naddeo
• Modalidade de apoio: Bolsas no Brasil - Doutorado