Chikungunya Virus Asian Lineage Infection in the Amazon Region Is Maintained by Asiatic and Caribbean-Introduced Variants

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Ribeiro, Geovani de Oliveira ; Gill, Danielle Elise ; Foro Ramos, Endrya do Socorro ; Villanova, Fabiola ; D'Athaide Ribeiro, Edcelha Soares ; Costa Monteiro, Fred Julio ; Morais, Vanessa S. ; Rego, Marlisson Octavio da S. ; Lima Araujo, Emerson Luiz ; Pandey, Ramendra Pati ; Raj, V. Samuel ; Deng, Xutao ; Delwart, Eric ; da Costa, Antonio Charlys ; Leal, Elcio

• Tipo de documento: Artigo Científico
• Fonte: Viruses-Basel; v. 14, n. 7, p. 14-pg., 2022-07-01.

Resumo

The simultaneous transmission of two lineages of the chikungunya virus (CHIKV) was discovered after the pathogen's initial arrival in Brazil. In Oiapoque (Amapa state, north Brazil), the Asian lineage (CHIKV-Asian) was discovered, while in Bahia state, the East-Central-South-African lineage (CHIKV-ECSA) was discovered (northeast Brazil). Since then, the CHIKV-Asian lineage has been restricted to the Amazon region (mostly in the state of Amapa), whereas the ECSA lineage has expanded across the country. Despite the fact that the Asian lineage was already present in the Amazon region, the ECSA lineage brought from the northeast caused a large outbreak in the Amazonian state of Roraima (north Brazil) in 2017. Here, CHIKV spread in the Amazon region was studied by a Zika-Dengue-Chikungunya PCR assay in 824 serum samples collected between 2013 and 2016 from individuals with symptoms of viral infection in the Amapa state. We found 11 samples positive for CHIKV-Asian, and, from these samples, we were able to retrieve 10 full-length viral genomes. A comprehensive phylogenetic study revealed that nine CHIKV sequences came from a local transmission cluster related to Caribbean strains, whereas one sequence was related to sequences from the Philippines. These findings imply that CHIKV spread in different ways in Roraima and Amapa, despite the fact that both states had similar climatic circumstances and mosquito vector frequencies. (AU)

• Processo FAPESP: 19/21706-5 - Metagenômica viral de mosquitos capturados no Estado de São Paulo
• Beneficiário: Vanessa dos Santos Morais
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto