Recent Trends in Drug Development for the Treatment of Adenocarcinoma Breast Cancer: Thiazole, Triazole, and Thiosemicarbazone Analogues as Efficient Scaffolds

Autor(es)

Scarim, Caue Benito ; Chin, Chung Man

• Tipo de documento: Artigo Científico
• Fonte: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY; v. 22, n. 12, p. 37-pg., 2022-01-01.

Resumo

Thiazoles, triazoles, and thiosemicarbazones function as efficient scaffolds in compounds for the treatment of several illnesses, including cancers. In this review article, we have demonstrated various studies involving these three pharmacophore classes (thiazoles, triazoles, and thiosemicarbazones) in medicinal chemistry over the last decade (2011-2021) with a focus on MCF-7 adenocarcinoma breast cancer cells. Our objective is to facilitate drug discovery of novel chemotherapeutic agents by detailing anti-proliferative compounds. (AU)

• Processo FAPESP: 16/10847-9 - Hidroximetilnitrofural (NFOH): estudo da atividade em fase crônica da Doença de Chagas em modelo animal e síntese de derivados solúveis
• Beneficiário: Cauê Benito Scarim
• Modalidade de apoio: Bolsas no Brasil - Doutorado