Preparation of Diorganomagnesium Reagents by Halogen-Lithium Exchange of Functionalized Heteroaryl Halides and Subsequent in situ Trapping with MgCl2 center dot LiCl in Continuous Flow

Autor(es)

Vicente Nishimura, Rodolfo Hideki ; Weidmann, Niels ; Knochel, Paul

• Tipo de documento: Artigo Científico
• Fonte: SYNTHESIS-STUTTGART; v. 52, n. 20, p. 11-pg., 2020-10-16.

Resumo

A halogen-lithium exchange in the presence of MgCl2 center dot LiCl on a broad range of heterocyclic scaffolds using a commercial flow set-up withnBuLi as exchange reagent is reported. The resulting diheteroarylmagnesium species were subsequently trapped with various electrophiles, such as ketones, aldehydes, allylic bromides, or disulfides affording functionalized heterocycles. A scale-up was performed by simply increasing the run-time without further optimizations. (AU)

• Processo FAPESP: 18/08856-5 - Metalações sobre condições de fluxo.
• Beneficiário: Rodolfo Hideki Vicente Nishimura
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado