Effects of photobiomodulation in experimental spinal cord injury models: A systematic review

Autor(es)

Tobelem, Daysi da Cruz ; Silva, Tamiris ; Araujo, Tamires ; Andreo, Lucas ; dos Santos Malavazzi, Taina Caroline ; Ratto Tempestini Horliana, Anna Carolina ; Santos Fernandes, Kristianne Porta ; Bussadori, Sandra Kalil ; Mesquita-Ferrari, Raquel Agnelli

• Tipo de documento: Artigo Científico
• Fonte: Journal of Biophotonics; v. 15, n. 8, p. 14-pg., 2022-05-19.

Resumo

This systematic review investigated the repercussions of photobiomodulation using low-level laser therapy (LLLT) for the treatment of spinal cord injury (SCI) in experimental models. Studies were identified from relevant databases published between January 2009 and December 2021. Nineteen original articles were selected and 68.4% used light at an infrared wavelength. There was a considerable variation of the power used (from 25 to 200 mW), total application time (8-3000 s) and total energy (0.3-450 J). In 79% of the studies, irradiation was initiated immediately after or within 2 h of the SCI, and treatment time ranged continuously from 5 to 21 days. In conclusion, LLLT can be an auxiliary therapy in the treatment of SCI, playing a neuroprotective role, enabling functional recovery, increasing the concentration of nerve connections around the injury site and reducing pro-inflammatory cytokines. However, there is a need for standardization in the dosimetric parameters. (AU)

• Processo FAPESP: 20/13976-0 - Avaliação dos efeitos da fotobiomodulação vascular sistêmica sobre o processo inflamatório e os aspectos morfológicos do tecido muscular durante o processo de reparo após lesão aguda
• Beneficiário: Raquel Agnelli Mesquita Ferrari
• Modalidade de apoio: Auxílio à Pesquisa - Regular