Vaccines, adjuvants and key factors for mucosal immune response

Autor(es)

Correa, Victor Araujo ; Portilho, Amanda Izeli ; De Gaspari, Elizabeth

• Tipo de documento: Artigo Científico
• Fonte: IMMUNOLOGY; v. 167, n. 2, p. 15-pg., 2022-07-12.

Resumo

Vaccines are the most effective tool to control infectious diseases, which provoke significant morbidity and mortality rates. Most vaccines are administered through the parenteral route and can elicit a robust systemic humoral response, but they induce a weak T-cell-mediated immunity and are poor inducers of mucosal protection. Considering that most pathogens enter the body through mucosal surfaces, a vaccine that elicits protection in the first site of contact between the host and the pathogen is promising. However, despite the advantages of mucosal vaccines as good options to confer protection on the mucosal surface, only a few mucosal vaccines are currently approved. In this review, we discuss the impact of vaccine administration in different mucosal surfaces; how appropriate adjuvants enhance the induction of protective mucosal immunity and other factors that can influence the mucosal immune response to vaccines. (AU)

• Processo FAPESP: 18/17945-1 - Estudo comparativo das técnicas de ELISA e ELISPOT na detecção de Anticorpos IgG, IgM em linhagens isogênicas de camundongos idosos
• Beneficiário: Thais Sousa Rodrigues
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 19/02042-9 - Avaliação dos perfis de resposta Th1 e Th2 em camundongos imunizados com lípides catiônicos e aniônicos complexados a vesículas de membrana externa de Neisseria meningitis b
• Beneficiário: Victor Araujo Correa
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 12/15568-0 - Estudo da imunogenicidade de antígenos de membrana externa de Neisseria meningitidis, e interação com lípides catiônicos: avaliação de diferentes vias de imunização em diferentes linhagens de camundongos
• Beneficiário: Elizabeth Natal de Gaspari
• Modalidade de apoio: Auxílio à Pesquisa - Regular