ANNEXIN A1: Roles in Placenta, Cell Survival, and Nucleus

Autor(es)

de Sousa, Stefanie Oliveira ; dos Santos, Mayk Ricardo ; Teixeira, Samuel Cota ; Ferro, Eloisa Amalia Vieira ; Oliani, Sonia Maria

• Tipo de documento: Artigo Científico
• Fonte: CELLS; v. 11, n. 13, p. 9-pg., 2022-07-01.

Resumo

The unbiased approaches of the last decade have enabled the collection of new data on the biology of annexin A1 (ANXA1) in a variety of scientific aspects, creating opportunities for new biomarkers and/or therapeutic purposes. ANXA1 is found in the plasma membrane, cytoplasm, and nucleus, being described at low levels in the nuclear and cytoplasmic compartments of placental cells related to gestational diabetic diseases, and its translocation from the cytoplasm to the nucleus has been associated with a response to DNA damage. The approaches presented here open pathways for reflection upon, and intrinsic clarification of, the modulating action of this protein in the response to genetic material damage, as well as its level of expression and cellular localization. The objective of this study is to arouse interest, with an emphasis on the mechanisms of nuclear translocation of ANXA1, which remain underexplored and may be beneficial in new inflammatory therapies. (AU)

• Processo FAPESP: 19/19949-7 - Avaliação da atividade imunomoduladora da proteína anexina A1 em lesões cutâneas e placentárias resultantes do Diabetes Mellitus
• Beneficiário: Sonia Maria Oliani
• Modalidade de apoio: Auxílio à Pesquisa - Regular