Synthesis and Antibacterial Activity of Maleimides

Autor(es)

Conrado, E. ; Francisco, C. J. ; Piccoli, R. H. ; Uchoa, A. F. ; Bastos-Filho, TF ; Caldeira, EMD ; Frizera-Neto, A

• Tipo de documento: Artigo Científico
• Fonte: XXVII BRAZILIAN CONGRESS ON BIOMEDICAL ENGINEERING, CBEB 2020; v. N/A, p. 5-pg., 2022-01-01.

Resumo

Previous studies have shown that cyclic imides and their subclasses have obtained positive results in biological activities, showing antimicrobial, analgesic and antifungal therapeutic potential. Arousing the interest of the scientific community and the pharmaceutical industry, surpassing expectations in relation to certain drugs used in the market. In this work we specifically perform the synthesis of one of the subclasses of cyclic imides, called maleimides, as they are easy to obtain and with good yields, in addition to being versatile for conjugation with other molecules. The synthesized compounds were identified by 1H and 13C nuclear magnetic resonance, mass spectroscopy and antibacterial activity was analyzed. In this work, a maleimide platform was obtained with different functional groups. These molecules showed synthesis yields (90%) and the activity was superior to the antibiotic streptomycin. (AU)

• Processo FAPESP: 13/07937-8 - Redoxoma
• Beneficiário: Ohara Augusto
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs