Plakilactone J: Structure and absolute configuration

Autor(es)

Batista, Andrea N. L. ; Brito, Mateus F. ; Batista Jr, Joao M. ; Valverde, Alessandra L.

• Tipo de documento: Artigo Científico
• Fonte: Tetrahedron Letters; v. 112, p. 4-pg., 2022-11-21.

Resumo

The chemical investigation of the Brazilian marine sponge Plakortis angulospiculatus led to the isolation of the new peroxide-derived polyketide plakilactone J (1). The structure of (-)-1 was established by means of HRMS and NMR analysis, while its absolute configuration was unambiguously determined as (4R,6R) by vibrational circular dichroism spectroscopy and density functional theory calculations.(c) 2022 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 19/22319-5 - Marcadores espectrais de dicroísmo circular vibracional: facilitando o assinalamento da configuração absoluta de produtos naturais
• Beneficiário: João Marcos Batista Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular