Hydroalcoholic Extract of Myrcia bella Loaded into a Microemulsion System: A Study of Antifungal and Mutagenic Potential

Autor(es):Mostrar menos -

Marena, Gabriel Davi ; Girotto, Luiza ; Saldanha, Luiz Leonardo ; Ramos, Matheus Aparecido dos Santos ; De Grandis, Rone Aparecido ; da Silva, Patricia Bento ; Dokkedal, Anne Ligia ; Chorilli, Marlus ; Bauab, Tais Maria ; Pavan, Fernando Rogerio ; Trovatti, Eliane ; Lustri, Wilton Rogerio ; Resende, Flavia Ap.

• Tipo de documento: Artigo Científico
• Fonte: Planta Medica; v. 88, n. 05, p. 11-pg., 2021-01-28.

Resumo

Myrcia bella is a medicinal plant used for the treatment of diabetes, hemorrhages, and hypertension in Brazilian folk medicine. Considering that plant extracts are attractive sources of new drugs, the aim of the present study was to verify the influence of incorporating 70% hydroalcoholic of M. bella leaves in nanostructured lipid systems on the mutagenic and antifungal activities of the extract. In this work, we evaluated the antifungal potential of M. bella loaded on the microemulsion against Candida sp for minimum inhibitory concentration, using the microdilution technique. The system was composed of polyoxyethylene 20 cetyl ether and soybean phosphatidylcholine (10%), grape seed oil, cholesterol (10%: proportion 5/1), and purified water (80%). To investigate the mutagenic activity, the Ames test was used with the Salmonella Typhimurium tester strains. M. bella, either incorporated or free, showed an important antifungal effect against all tested strains. Moreover, the incorporation surprisingly inhibited the mutagenicity presented by the extract. The present study attests the antimicrobial properties of M. bella extract, contributing to the search for new natural products with biological activities and suggesting caution in its use for medicinal purposes. In addition, the results emphasize the importance of the use of nanotechnology associated with natural products as a strategy for the control of infections caused mainly by the genus Candida sp. (AU)

• Processo FAPESP: 17/18782-6 - Plataforma click chemistry aplicada ao desenvolvimento de materiais poliméricos para uso em medicina regenerativa
• Beneficiário: Eliane Trovatti
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 17/16278-9 - Estudo do potencial genotoxicológico e da permeabilidade em células Caco-2 de complexos metálicos com promissoras atividades biológicas
• Beneficiário: Flávia Aparecida Resende Nogueira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/12590-0 - Síntese de complexos metálicos com ligantes bioativos N,N ou N,O-coordenantes para utilização em dispositivos de liberação sustentada baseados em celulose bacteriana
• Beneficiário: Wilton Rogério Lustri
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/08559-5 - Análise química e prospecção terapêutica de Syngonanthus nitens (Bong.) Ruhland e Cymbopogon nardus (L.) Rendle incorporados em sistemas nanotecnológicos aplicados ao tratamento da candidíase vulvovaginal
• Beneficiário: Taís Maria Bauab
• Modalidade de apoio: Auxílio à Pesquisa - Regular