Species-specific molecular differentiation of embryonic inner cell mass and trophectoderm: A systematic review

Autor(es)

Marsico, Thamiris Vieira ; Valente, Roniele Santana ; Annes, Kelly ; Oliveira, Andressa Minozzo ; Silva, Mara Viana ; Sudano, Mateus Jose

• Tipo de documento: Artigo Científico
• Fonte: Animal Reproduction Science; v. 252, p. 11-pg., 2023-04-18.

Resumo

A wide-ranging review study regarding the molecular characterization of the first cell lineages of the developmental embryo is lacking, especially for the primary events during earliest differentiation which leads to the determination of cellular fate. Here, a systematic review and meta-analysis were conducted according to PRISMA guidelines. MEDLINE-PubMed was searched based on an established search strategy through April 2021. Thirty-six studies fulfilling the inclusion criteria were subjected to qualitative and quantitative analysis. Among the studies, 50 % (18/36) used mice as an animal model, 22.2 % (8/36) pigs, 16.7 % (6/36) cattle, 5.5 % (2/36) humans, and 2.8 % (1/36) goats as well as 2.8 % (1/36) equine. Our results demonstrated that each of the first cell lineages of embryos requires a certain pattern of expression to establish the cellular determination of fate. Moreover, these patterns are shared by many species, particularly for those molecules that have already been identified in the literature as biomarkers. In conclusion, the present study integrated carefully chosen studies regarding embryonic development and first cellular decisions in mammalian species and summarized the information about the differential characterization of the first cell lineages and their possible relationship with specific gene expression. (AU)

• Processo FAPESP: 19/17796-9 - Biopsia simultânea e perfil lipídico da massa celular interna e trofectoderma embrionário
• Beneficiário: Thamiris Vieira Marsico
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/21496-8 - Caminhos para prenhez embrionária
• Beneficiário: Mateus José Sudano
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 20/08826-9 - Investigação do sistema de membranas celulares e sua relação com a criotolerância e viabilidade de embriões bovinos produzidos in vitro
• Beneficiário: Kelly Annes
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 22/02139-5 - Perfil transcricional da competência embrionária
• Beneficiário: Andressa Minozzo Oliveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 19/18415-9 - Papel das vias inflamatórias sobre a competência e criotolerância embrionária
• Beneficiário: Roniele Santana Valente
• Modalidade de apoio: Bolsas no Brasil - Doutorado