Natural component and solid lipid microparticles of solar filter in sunscreen: Photoprotective and photostability effect enhancement

Autor(es)

Martins, Rodrigo Molina ; Martins, Silvia de Siqueira ; Barbosa, Gustavo Luis Ferreira ; Silva, Eullallia Goncalo das Neves e ; Fonseca, Maria Jose Vieira ; Freitas, Luis Alexandre Pedro de

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY; v. 88, p. 10-pg., 2023-08-31.

Resumo

A topical formulation containing a natural compound (rutin), in association with UVA filter solid lipid micro-particles (SLMs) was prepared aiming to decrease the photodegradation of the UV filter and evaluate whether the sunscreen's photoprotection was impaired by the microencapsulation process caused by UVA radiation. The SLMs were manufactured by spray congealing using a factorial central composite design. The optimum condi-tions for the preparation were a UVA filter content of 60.5%, flow rate of 6.76 mL/min, and airflow rate of 2.84 m3/min. SLMs presented a mean size of 29.6 mu m, polydispersity index of 1.74, encapsulation efficiency of 100%. The topical formulation showed that the microencapsulation process and the free rutin were able to reverse avobenzone photodegradation. In addition, the formulation promoted photoprotection, showing that the microencapsulation process associated with the rutin is promising for use in sunscreens. (AU)

• Processo FAPESP: 10/11602-3 - Desenvolvimento farmacotécnico e avaliação fotoquimiopreventiva de uma formulação contendo associação de filtros solares e rutina
• Beneficiário: Rodrigo Molina Martins
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 08/02848-9 - Estudo da Técnica de "Spray Congealing" para produção de dispersões sólidas contendo fármacos de baixa solubilidade
• Beneficiário: Luis Alexandre Pedro de Freitas
• Modalidade de apoio: Auxílio à Pesquisa - Regular