| Texto completo | |
| Autor(es): Mostrar menos - |
Dobson, Luca S.
;
Zhang, Qingzhi
;
Mckay, Benjamin A.
;
Oke, Oluwayinka
;
Isanbor, Chukwuemeka
;
Khan, Mohd Faheem
;
Piscelli, Bruno A.
;
Cordes, David B.
;
Cormanich, Rodrigo A.
;
Murphy, Cormac D.
;
O'Hagan, David
Número total de Autores: 11
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ORGANIC LETTERS; v. 25, n. 37, p. 6-pg., 2023-09-08. |
| Resumo | |
The (ss,ss ',ss ''-trifluoro)-tert-butyl (TFTB) group has received very little attention in the literature. This work presents a direct synthesis of this group and explores its properties. The TFTB group arises when the methyl groups of a tert-butyl moiety are exchanged for fluoromethyl groups. Sequential fluoromethylations result in a decrease of Log P (increasing hydrophilicity), ultimately by 1.7 Log P units in the TFTB group relative to that of tert-butyl benzene itself. A focus is placed on synthetic transformations, conformational analysis, and metabolism of the TFTB group in the context of presenting a favorable profile as a motif for the discovery of bioactives. (AU) | |
| Processo FAPESP: | 22/10156-7 - Estudo experimental e teórico dos efeitos estereoeletrônicos e arranjo supramolecular de compostos organofluorados |
| Beneficiário: | Bruno de Almeida Piscelli |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 18/03910-1 - Estudos físico-químicos de compostos orgânicos fluorados: abordagens experimental e teórica |
| Beneficiário: | Rodrigo Antonio Cormanich |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |