| Texto completo | |
| Autor(es): |
Londe, Ana Carolina
;
Fernandez-Ruiz, Ruth
;
Julio, Paulo Rogerio
;
Appenzeller, Simone
;
Niewold, Timothy B.
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF RHEUMATOLOGY; v. 50, n. 9, p. 11-pg., 2023-09-01. |
| Resumo | |
Type I interferon (IFN-I) is thought to play a role in many systemic autoimmune diseases. IFN-I pathway activation is associated with pathogenic features, including the presence of autoantibodies and clinical phenotypes such as more severe disease with increased disease activity and damage. We will review the role and potential drivers of IFN-I dysregulation in 5 prototypic autoimmune diseases: systemic lupus erythematosus, dermatomyositis, rheumatoid arthritis, primary Sjogren syndrome, and systemic sclerosis. We will also discuss current therapeutic strategies that directly or indirectly target the IFN-I system. (AU) | |
| Processo FAPESP: | 08/02917-0 - Determinação de marcadores séricos e do líquor associados a alterações estruturais e funcionais do sistema nervoso central no lúpus eritematoso sistêmico |
| Beneficiário: | Simone Appenzeller |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 16/23269-3 - MicroRNAs do gene TNFa no lúpus eritematoso sistêmico: potenciais biomarcadores |
| Beneficiário: | Mariana Postal Zink de Souza |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |